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Method for identifying sampling points of biological chip on basis of edge detection

A biochip and edge detection technology, applied in the field of image recognition, can solve problems such as difficult to guarantee data repeatability and reliability, low degree of automation, inaccurate sample point positioning, etc., to facilitate medical analysis, simple software implementation, The effect of easy operation

Inactive Publication Date: 2011-05-25
INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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Problems solved by technology

[0004] In view of the defects that the existing technology needs to manually input the number of rows and columns of the chip array, the radius of the sample point and the row and column spacing of the array, the positioning of the sample point is not accurate, the data repeatability and reliability are difficult to be guaranteed, and the degree of automation is not high. The purpose of the present invention is to propose a kind of identification method based on edge detection biochip image samples

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  • Method for identifying sampling points of biological chip on basis of edge detection
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  • Method for identifying sampling points of biological chip on basis of edge detection

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[0017] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0018] attached Figure 5 It shows that the whole process is realized by VC++ 6.0 programming, and it is realized in the EBS-1 portable biochip detection system. Among them, the main parameters of the portable biochip detection system are uniform illumination 1%@2CM 2 , lighting area 2CM 2 , The image acquisition speed is 24 frames per second. At the same time, the present invention will be described in further detail with reference to the accompanying drawings.

[0019] Step S1: Continuously take multiple images of the biochip, synthesize and take the average value as the original image;

[0020] Step S2: Extract the sample point edge from the original image, apply the expansion operation in morphology to the sample ...

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Abstract

The invention discloses a method for identifying sampling points of a biological chip on the basis of the edge detection. The method comprises the following steps of: firstly, determining a real area of the sampling points by edge extraction, edge connection and area filling; then meshing by adopting a scanning method and automatically obtaining the row number, the column number and the total number; and finally corresponding area positions of the sampling points in each determined mesh to an original drawing, carrying out automatic searching to obtain the area and the mean value of gray scale of the sampling points in the original drawing, and comparing the area and the value of gray scale of the sampling points in the original drawing with corresponding parameters of the sampling pointsin the standard chip to obtain an automatic identification result of the sampling points. The method has high positioning accuracy. Software of the method is simpler to implement. The method has short time of an algorithm, is convenient and rapid to operate and makes full automation and intellectualization of information extraction of the biological chip possible.

Description

technical field [0001] The invention belongs to the technical field of image recognition, and relates to a method for recognizing sample points of a biochip image, in particular to a method for recognizing sample points of a biochip image based on edge detection. Background technique [0002] A biochip is an orderly array of a series of addressable recognition molecules fixed at a certain position on the surface of a small substrate, and these spot molecules carry a large amount of biological information. Through screening and detection analysis, people can quickly obtain biological information in samples. Therefore, biochip technology has become an important tool for life scientists to study gene expression analysis, disease diagnosis, new drug discovery and many other fields. [0003] The biochip information processing process is to analyze the absorbance value, area or absorbance ratio of the sample points of the imaging results of the biochip. Important biological info...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06K9/64G06T5/00
Inventor 胡松严伟李艳丽
Owner INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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