Medicament for treating cyclomastopathy and preparation method and application thereof

A breast hyperplasia and drug technology, applied in the field of pharmacology, can solve problems such as difficult recovery of histological changes, large side effects, and large damage

Active Publication Date: 2011-02-23
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hyperplasia of mammary glands is an endocrine system disease. There is no indication for surgical treatment, and the damage caused by surgical treatment is large.
In short, western medicine treatment of this disease mostly on

Method used

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  • Medicament for treating cyclomastopathy and preparation method and application thereof
  • Medicament for treating cyclomastopathy and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The medicine for treating mammary gland hyperplasia is a medicament made from the following weight ratio of raw materials:

[0036] Prepare 15 parts of aconite, 10 parts of Evodia rutaecarpa, 20 parts of dried ginger, 20 parts of sautéed rhizome, 10 parts of Chuanxiong, 15 parts of bergamot, 10 parts of amomum, 9 parts of burnt Phellodendron, 10 parts of roasted licorice, and 60 parts of bromeliad.

[0037] Add water to decoct all the above-mentioned raw materials for 3 times, respectively 10 times the amount of water for 2 hours, 8 times the amount of water for 2 hours, and 8 times the amount of water for 2 hours, combine the decoctions, filter, and concentrate the filtrate at 80°C to a relative density of 1.25 , let it cool to room temperature, add ethanol to make the alcohol content reach 80%, let it stand for 24 hours, take the supernatant to recover ethanol, concentrate at 80°C to an extract with a relative density of about 1.30, and vacuum reduce it at 80°C. Press...

Embodiment 2

[0039] The fine powder that embodiment 1 makes, add sucrose powder and dextrin, its ratio is medicine fine powder: sucrose powder: dextrin is 3: 2: 1, mix, add 75% ethanol and make soft material, spray granulation, Drying, granulation, sub-packaging to obtain granules, the packing specification is 8g×3 bags. Each gram of granule is equivalent to 14g of raw medicinal material.

Embodiment 3

[0041] Prove that Chinese medicine compound of the present invention has good curative effect by pharmacodynamic experiment below.

[0042] The fine powder described in embodiment 1 is used as experimental method and result of experimental medicine:

[0043] On the basis of referring to relevant literature, the present invention uses estradiol benzoate and progesterone to induce mammary gland hyperplasia in rats, and uses this method to replicate a mammary gland hyperplasia model. Experimental Study.

[0044] 72 healthy wistar female non-pregnant rats, body weight 160~180g, were randomly divided into 6 groups, 12 in each group, respectively normal control group, model group, low, middle and high dose groups of pharmaceutical composition and positive drug group ( Ru Zeng Ning). Except for the normal control group, each rat in the other groups was intramuscularly injected with estradiol benzoate 0.5 mg / kg, once / d, for 30 days, and then intramuscularly injected with progesteron...

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Abstract

The invention discloses a medicament for treating cyclomastopathy and a preparation method and application thereof. The medicament of the invention mainly comprises 10 medicaments, namely prepared common monkshood daughter root, medicinal evodia fruit, dried ginger, fried nutgrass galingale rhizome, szechuan lovage rhizome, finger citron, amomum fruit, burnt amur corktree bark, roasted liquoric root and sageretia theezans, extraction is performed according to the physicochemical property of active ingredients of each medicament, and an oral solid or liquid preparation is prepared according to the conventional method. The medicament focuses on warming liver and kidney, regulating conception and thoroughfare vessels and resolving hard lump, and also has the effects of soothing liver, regulating the flow of vital energy, promoting blood circulation, removing blood stasis, removing poison and promoting tissue regeneration. A clinical trial proves that: the medicament has exact curative effect on the cyclomastopathy, benign mastadenoma, hysteromyoma and lymphocele, also can be applied to the treatment of breast cancer, and has important medicinal value.

Description

Technical field: [0001] The invention belongs to the field of pharmacy, and in particular relates to a traditional Chinese medicine compound preparation for treating hyperplasia of mammary glands, benign breast tumors, uterine fibroids and lymphatic cysts, its preparation method and its preparation method for treating hyperplasia of mammary glands, benign breast tumors and uterine fibroids. , the application in the medicine of lymphocyst disease, the application in the preparation of the medicine for treating the disease of breast cancer. Background technique: [0002] Hyperplasia of the mammary glands, also known as breast dysplasia, fibrocystic mastopathy, is a disease that combines a variety of clinical symptoms, including cyst-based (simple cyst), adenosis-based, and fibroadenoma-like structures. type, intraductal papilloma predominant type (excluding solitary and multiple intraductal papilloma), atypical hyperplasia, etc. Clinical data generally believe that there are ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P15/00A61P15/14A61P43/00
Inventor 程永现李立纪陈小亮
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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