Molecular staging of stage II and III colon cancer and prognosis

Abstract

Kits and articles include reagents for conducting a seven gene assay to stage colon cancer as Stage II or Stage III colon cancer.

Description

Background technique [0001] Accurate staging of colon cancer is not only beneficial to the prognosis of the disease, but also beneficial to the clinical management and treatment selection of patients. The TNM system based on clinical and pathological features was introduced in the 1940s and gradually evolved to become widely adopted after the 1980s (Quirke et al. (2007)). In these guidelines, adequate lymph node assessment is essential for correct staging of colon cancer. However, due to patient, surgeon, pathologist, and tumor-related variables, 63% of patients with colon cancer may not have adequate lymph node assessment. (Baxter et al. (2005)). [0002] Genomic approaches have been successfully applied to identification of cancer classes and subclasses, prediction of disease progression, and prediction of treatment selection and efficacy (Bhattacharjee et al. (2001); Khan et al. (2001); Sorlie et al. (2003); Agrawal et al. ( 2002); and Wang et al. (2005)). Genetic and e...

AI Technical Summary

Problems solved by technology

However, due to patient, surgeon, pathologist, and tumor-related variables, 63% of patients with colon cancer may not have adequate lymph node assessment

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