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Preparation method of chitosan/ acetalized poval medical dressing

A technology of polyvinyl alcohol medicine and polyvinyl alcohol, applied in the field of preparation of polyvinyl alcohol sponge, can solve the problems of low strength, poor resistance to wound adhesion, easy to cause inflammation, etc., and achieve high porosity, good air permeability, and low price Effect

Inactive Publication Date: 2010-12-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently commercially available domestic medical sponges generally have disadvantages such as low strength, poor resistance to wound adhesion, and easy inflammation.

Method used

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  • Preparation method of chitosan/ acetalized poval medical dressing
  • Preparation method of chitosan/ acetalized poval medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 0.05g chitosan was dissolved in 5% dilute acetic acid aqueous solution to prepare a chitosan solution with a mass fraction of 1.0%. Dissolve 0.05 g of polyvinyl alcohol in 5 ml of boiling water to prepare a 1.0% polyvinyl alcohol solution. The above chitosan solution and polyvinyl alcohol solution are mixed at a volume ratio of 1:1 and then fully stirred to obtain a polyvinyl alcohol / chitosan blend. Weigh 20g of polyvinyl alcohol, dissolve it in 200mL of boiling water, cool down to 50°C, add 0.20g of sodium lauryl sulfate, 22mL of formaldehyde with a mass fraction of 37% and 2.0g of sodium bicarbonate, and stir at 1500r / min for 20min , add 20mL of hydrochloric acid with a mass fraction of 36% at 50°C, continue high-speed stirring to make the solution foam to the maximum volume, keep 50°C, and then drop 10ml of polyvinyl alcohol / chitosan blend into the foam and stir evenly. The foam is injected into a polypropylene mold. Curing at a constant temperature of 50° C. for 1...

Embodiment 2

[0028] Dissolve 0.05g of chitosan in 5% dilute acetic acid aqueous solution to prepare a chitosan solution with a mass fraction of 1.0%. Dissolve 0.05 g of polyvinyl alcohol in 5 ml of boiling water to prepare a 1.0% polyvinyl alcohol solution. The above chitosan solution and polyvinyl alcohol solution are mixed at a volume ratio of 1:1 and then fully stirred to obtain a polyvinyl alcohol / chitosan blend. Weigh 20g of polyvinyl alcohol, dissolve it in 120mL of boiling water, cool down to 35°C, add 0.10g of sodium lauryl sulfate, 20mL of formaldehyde with a mass fraction of 37% and 3.0g of sodium bicarbonate, and stir at 1500r / min for 20min , add 20mL of hydrochloric acid with a mass fraction of 36% at 35°C, continue to stir at 1500r / min to make the solution foam to the maximum volume, keep 35°C, then drop 10ml of polyvinyl alcohol / chitosan blend into the foam and stir Evenly, pour the foam into the polypropylene mold. Curing at a constant temperature of 60° C. for 10 h, takin...

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Abstract

The invention discloses a preparation method of chitosan / acetalized poval medical dressing, and in particular relates to a preparation technology of poval sponge. A dressing with bioactivity can be prepared by adding a poval / chitosan mixed solution in poval acetalation reaction. The chitosan / acetalized poval medical dressing has biocompatibility,the effects of inflammation, blood stopping, wound surface healing promotion, good breathability, water absorbability and tensile strength; in addition, proved by the search on toxic effect on mouse fibroblast cells, the chitosan / acetalized poval medical dressing has no obvious toxicity to the mouse fibroblast cells, but has the effect of promoting the growth of the mouse fibroblast cells.

Description

technical field [0001] The invention relates to the technical field of preparation of polyvinyl alcohol sponge, in particular to a preparation method of chitosan / acetalized polyvinyl alcohol medical dressing. Background technique [0002] Dressings are medical materials that can temporarily protect wounds, prevent infection, and promote healing. Research in recent years has shown that wounds heal faster in a moist environment. Under the guidance of the theory of "moist wound healing", and with the progress of material science and industrial science, revolutionary changes have taken place in wound medical dressings. Traditional gauze dressings that simply cover the role can no longer meet modern clinical needs. In recent years, new materials such as synthetic dressings, biological dressings, tissue engineering coverings, and nano dressings have emerged. They can not only fully protect the wound surface, but also promote tissue repair. Antibacterial sterilization and acceler...

Claims

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Application Information

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IPC IPC(8): A61L15/28C08L5/08C08L29/14C08L29/04C08F16/38
Inventor 魏坤曾晓峰
Owner SOUTH CHINA UNIV OF TECH
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