Smoke exposure device used for establishing chronic obstructive pulmonary disease model

Abstract

The invention discloses a smoke exposure device used for establishing a chronic obstructive pulmonary disease model. The smoke exposure device mainly comprises a flow regulating device, a peristaltic pump and a closed box, wherein the flow regulating device comprises a smoke inlet pipe, an air inlet pipe, a smoke outlet pipe, an air outlet pipe, a smoke flow regulator and an air flow regulator; the smoke flow regulator is communicated with the smoke inlet pipe and the smoke outlet pipe respectively; the air flow regulator is communicated with the air inlet pipe and the air outlet pipe respectively; the smoke outlet pipe, the air outlet pipe and an air duct are communicated with one another; and the air duct is communicated with the closed box and is arranged inside a pump bed of the peristaltic pump. The smoke exposure device has the advantages of precisely regulating the smoke flow and the ratio of the smoke flow to air, facilitating quantitative analysis, improving the stability, reliability and repeatability of an experiment, and effectively avoiding the suffocation death of experimental animals, the cigarette smoke inhalation of experiment operators and atmospheric pollution, along with simple structure, convenient manufacturing and low cost.

Description

technical field [0001] The invention relates to a smoke exposure device for establishing a model of chronic obstructive pulmonary disease, which belongs to the field of medical basic research experimental equipment. Background technique [0002] It has been clear that smoking is the most important pathogenic factor of human chronic obstructive pulmonary disease. Simulating the pathogenesis process, the animal model of emphysema induced by passive smoking of experimental animals through smoke exposure has been recognized by many researchers and is widely used in the research of the pathogenesis and clinical prevention and treatment of COPD. [0003] At present, domestic researchers mostly use fumigation devices to build animal COPD models. The reported methods are similar, which can be briefly described as follows: separate the upper and lower parts of the airtight container with a shelf with holes, and put the experimental animals on the shelf. , and then light a cigarette ...

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Problems solved by technology

Although these improved devices are commercially available, they are expensive and difficult to apply in most laboratories in my country.

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