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Ibuprofen and lysine medicament compound as well as preparation method and application thereof

A technology of lysine and composition, which is applied to the pharmaceutical composition of ibuprofen and lysine and the field of preparation thereof, can solve the problems of affecting the scope of application and clinical effect, being difficult to be prepared into oral solution preparations and injections, etc. The effect of improving production efficiency and simplifying the preparation process

Inactive Publication Date: 2010-11-03
航天中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because ibuprofen is almost insoluble in water, it is not easy to make oral solution preparations and injections, which affects its application range and clinical effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] prescription:

[0015] Ibuprofen: 100g

[0016] Lysine: 78g

[0017] Water for injection 1000ml

[0018] Preparation method: According to the process of small-capacity injection, first dissolve lysine in about 800ml of water, add ibuprofen while stirring until it is completely dissolved, add water for injection to 1000ml; absorb with activated carbon, decarbonize, followed by 0.45 micron, 0.22 micron microporous membrane filtration; after the filtrate content is qualified, it is filled in a washed, dried and sterilized ampoule, and melted; sterilized at 115°C for 30 minutes to make a finished product.

Embodiment 2

[0020] prescription:

[0021] Ibuprofen: 100g

[0022] Lysine: 78g

[0023] Water for injection 1000ml

[0024] Preparation method: According to the process of small-volume injection, mix ibuprofen and lysine, add about 800ml of water for injection, stir until it is completely dissolved, add water for injection to 1000ml; 0.45 micron, 0.22 micron microporous membrane filtration; after the filtrate content is qualified, it is filled in a washed, dried and sterilized ampoule, and melted; sterilized at 115°C for 30 minutes to make a finished product.

Embodiment 3

[0026] prescription:

[0027] Ibuprofen: 100g

[0028] Lysine: 78g

[0029] Water for injection 1000ml

[0030] Preparation method: According to the preparation process of oral liquid, first dissolve lysine in about 800ml of water, add ibuprofen while stirring until completely dissolved, add flavoring agent, etc., add water for injection to 1000ml, filter After the determination of the filtrate content is qualified, it is filled in the oral liquid bottle that has been washed, dried and sterilized, and sealed; sterilized at 115° C. for 30 minutes to make a finished product.

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PUM

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Abstract

The invention discloses an ibuprofen and lysine medicament compound as well as a preparation method and the application thereof. The medicament compound contains ibuprofen and lysine in the mole ratio of 1:0.5-1:2. An aqueous solution preparation of the medicament compound can be prepared by firstly dissolving lysine into water to form a lysine solution, and then dissolving ibuprofen into the lysine solution to form the aqueous solution of ibuprofen and lysine. The medicament compound is used for refrigerating, easing pain, resisting inflammation, resisting rheumatism and treating unclosed ductus arteriosus, and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a pharmaceutical composition of ibuprofen and lysine, a preparation method and application thereof. Background technique [0002] Ibuprofen is a phenylpropionic acid non-steroidal anti-inflammatory drug, which has antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects, and has few adverse reactions. It is an antipyretic and analgesic widely used at present. At present, the dosage forms of ibuprofen on the market in China include ordinary tablets, sustained-release tablets, capsules, suspensions, suppositories, creams, etc. [0003] Because ibuprofen is almost insoluble in water, it is difficult to make oral solution preparations and injections, which affects its application range and clinical effect. [0004] U.S. Patent No. 6,342,530 B1 mentioned the prescription and preparation method of parenteral administration of ibuprofen lysine salt. Chinese patent CN1302771...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K47/16A61P29/00
Inventor 刘会臣韩静王涛
Owner 航天中心医院
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