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Fructose diphosphate sodium liposome solid preparation and novel application thereof

The technology of sodium fructose diphosphate and sodium diphosphate lipid is applied in the field of sodium fructose diphosphate liposome and its preparation, which can solve the problems of low curative effect, poor absorption and the like, and achieves improvement of therapeutic index, reduction of drug toxicity and production technology simple effect

Inactive Publication Date: 2010-11-03
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method involves making certain types of pharmaceutical compositions containing different ingredients that help improve their ability to deliver medicine more effectively for better patient outcomes. These new methods have several benefits over existing ones such as reducing dosage errors or increasing bioavailability while also being safe from harmful chemicals associated therewith.

Problems solved by technology

This patented technical solution describes different ways to make drugs like sildenafil citrate (SM) more effective at treating cancer diseases such as lung carcinoma, breast cancer, renal failure, cardiovascular events, stroke, necrosis, chronotropic recessive syndrome, autoimmunity, and others associated with aging. Additionally, this patent discusses how certain chemicals called salts could stimuate specific areas involved in these processes.

Method used

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  • Fructose diphosphate sodium liposome solid preparation and novel application thereof
  • Fructose diphosphate sodium liposome solid preparation and novel application thereof
  • Fructose diphosphate sodium liposome solid preparation and novel application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Preparation of sodium fructose diphosphate liposomes

[0065] Prescription: Sodium Fructose Diphosphate 250g

[0066] Soy Lecithin 450g

[0067] Cholesterol 125g

[0068] Polyglycerol ester 50g

[0069] Preparation Process

[0070] (1) Dissolve 450g soybean lecithin, 125g cholesterol, and 50g polyglycerol ester in 2000ml ethanol, mix well, and remove ethanol under reduced pressure on a rotary thin film evaporator to obtain a phospholipid film;

[0071] (2) Add 1200ml of sodium dihydrogen phosphate-disodium hydrogen phosphate buffer solution with a pH value of 5.5, shake, stir for 20min, and rotate at a speed of 600r / min to completely hydrate the phospholipid membrane, then homogeneously emulsify with a tissue masher for 10min, and rotate at a speed of 600r / min. 15000r / min, and then filter with a 0.45 μm microporous membrane to obtain a blank liposome suspension;

[0072] (3) Dissolve 250g sodium fructose diphosphate in 1000ml water, f...

Embodiment 2

[0080] Example 2 Preparation of sodium fructose diphosphate liposomes

[0081] Prescription: Sodium Fructose Diphosphate 250g

[0082] Soy Lecithin 1250g

[0083] Cholesterol 1000g

[0084] Polyglycerol ester 500g

[0085] Preparation Process

[0086] (1) Dissolve 1250g soybean lecithin, 1000g cholesterol, and 500g polyglycerol ester in 16000ml isopropanol, mix well, remove isopropanol under reduced pressure on a rotary thin film evaporator, and obtain a phospholipid film;

[0087] (2) Add 12000ml of citric acid-sodium citrate buffer solution with a pH value of 6.5, shake, stir for 40min, and rotate at a speed of 200r / min to completely hydrate the phospholipid membrane, then homogeneously emulsify with a tissue masher for 20min, and rotate at a speed of 200r / min. 12000 / min, and then filter with a 0.45 μm microporous membrane to obtain a blank liposome suspension;

[0088] (3) Dissolve 250g of sodium fructose diphosphate in 2000ml of water, filter thr...

Embodiment 3

[0100] Example 3 Preparation of Sodium Fructose Diphosphate Granules

[0101] Prescription (100 tablets)

[0102] Sodium fructose diphosphate liposome (calculated as sodium fructose diphosphate) 25g

[0103] Mannitol 45g

[0104] Lactose 30g

[0105]Carboxymethyl Starch Sodium 5g

[0106] Sucrose 50g

[0107] Aspartame 2.5g

[0108] Povidone K30 2.5g

[0109] Preparation Process

[0110] (1) pulverize the liposome containing 25g sodium fructose diphosphate prepared in Example 1, cross 80 mesh sieves, and set aside;

[0111] (2) Take by weighing 45g mannitol, 30g lactose, 5g sodium starch glycolate, 50g sucrose and 2.5g aspartame, cross 80 mesh sieves, mix and set aside;

[0112] (3) Mix the above raw and auxiliary materials evenly, add 5% povidone K 30 50ml of 80% ethanol solution is used to make soft materials, pass through a 20-mesh sieve to granulate, dry at 60°C, and granulate through a 18-mesh sieve to obtain sodium fructose diphosphate granules;

[0113] (4...

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Abstract

The invention provides a fructose diphosphate sodium liposome solid preparation and a novel application thereof. The fructose diphosphate sodium liposome solid preparation is prepared from fructose diphosphate sodium liposome and auxiliary materials, wherein the fructose diphosphate sodium liposome is prepared from fructose diphosphate sodium, lecithin, cholesterol and polyglycerin ester. The invention also provides the application of the fructose diphosphate sodium liposome solid preparation in improving the immunity of tumor patients undergoing chemotherapy. The fructose diphosphate sodium liposome can be prepared by adopting a thin-film dispersion technology to combine a certain amount of the lecithin, the cholesterol, the polyglycerin ester and the active component fructose diphosphate sodium, and is mixed with a certain amount of the auxiliary materials to prepare various solid preparations, so the invention can well solve the problems of poor in-vivo absorption degree and low curative effect, and obtains satisfactory technical effect.

Description

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Claims

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Application Information

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Owner HAINAN MEILAN SMITH KLINE PHARMA
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