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A traditional Chinese medicine composition for treating premature ovarian failure and its preparation method

A technology for premature ovarian failure and composition, which is applied in the field of traditional Chinese medicine composition for treating premature ovarian failure and its preparation field, can solve the problems of inducing endometrial cancer, breast cancer, high recurrence rate, psychological disorder in hormone use and the like

Active Publication Date: 2012-02-22
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine adopts HRT method, the recurrence rate is high after discontinuation, and long-term application may induce endometrial cancer, breast cancer, and patients with blood system diseases such as uterine fibroids, breast hyperplasia, diabetes and thrombosis should not take it. Some women have psychological barriers to hormone use

Method used

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  • A traditional Chinese medicine composition for treating premature ovarian failure and its preparation method
  • A traditional Chinese medicine composition for treating premature ovarian failure and its preparation method
  • A traditional Chinese medicine composition for treating premature ovarian failure and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0217] Embodiment 1: Capsules

[0218] prescription:

[0219] Rehmannia glutinosa 180g Dogwood 180g Angelica 180g

[0220] Paeoniae Alba 180g Epimedium 180g Salvia 90g

[0221] Preparation method: (1) Take Salvia miltiorrhiza, add 8 times the amount of 90% ethanol to extract twice, each time for 1 hour, combine the extracts, recover the ethanol under reduced pressure and concentrate to 60 ° C. Dry to get dry cream I;

[0222] (2) Take Radix Paeoniae Alba and Epimedium and add 16 times the amount and 14 times the amount of water to extract twice, each time for 1.5 hours, combine the extracts, concentrate under reduced pressure to an extract with a relative density of 1.10 to 1.15 at 60°C, and put Cool, add ethanol to make the alcohol content reach 70%, let it stand for 12 hours, concentrate the supernatant under reduced pressure to an extract with a relative density of 1.10-1.15 at 60°C, let it cool, add ethanol to make the alcohol content reach 80%, stand still After leavi...

Embodiment 2

[0227] Embodiment 2: capsules

[0228] Rehmannia glutinosa 240g Dogwood 240g Angelica 160g

[0229] White peony 160g Epimedium 160g Salvia 80g

[0230] Preparation method: (1) take Salvia miltiorrhiza, add 4 times the amount of 70% ethanol to extract 3 times, each time for 0.5 hours, combine the extracts, concentrate and dry to obtain dry cream I;

[0231] (2) Take Radix Paeoniae Alba and Epimedium and add 8 times the amount of water to decoct and extract 3 times, 0.5 hours each time, combine the extracts, concentrate, let cool, add ethanol to make the alcohol content reach 60%, let stand, take Concentrate the supernatant to the extract, let it cool, add ethanol to make the alcohol content reach 75%, let stand, take the supernatant and concentrate to the extract, dry to obtain the dry extract II;

[0232] (3) Take Chinese angelica, Rehmannia glutinosa, and Cornus officinalis, add 4 times the amount of water to decoct and extract 3 times, 1 hour each time, combine the extract...

Embodiment 3

[0236] Embodiment 3: capsules

[0237] Rehmannia glutinosa 210g Dogwood 210g Angelica 140g

[0238] Radix Paeoniae Alba 140g Epimedium 140g Salvia miltiorrhiza 140g.

[0239] Preparation method: (1) take Salvia miltiorrhiza, add 5 times the amount of 75% ethanol to reflux and extract for 3 times, each time for 0.5 hours, combine the extracts, concentrate and dry to obtain dry cream I;

[0240] (2) Take Radix Paeoniae Alba and Epimedium and add 9 times the amount of water to extract 3 times, each time for 0.5 hours, combine the extracts, concentrate, let cool, add ethanol to make the alcohol content reach 60%, let it stand, and take the supernatant Concentrate to the extract, let it cool, add ethanol to make the alcohol content reach 75%, let it stand, take the supernatant and concentrate to the extract, dry to obtain dry extract II;

[0241] (3) Take angelica, Rehmannia glutinosa, and Cornus officinalis and add 12 times the amount of water to extract once, 3 hours each time,...

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Abstract

The invention provides a traditional Chinese medicine composition for treating premature ovarian failure. The composition is made of the following traditional Chinese medicine raw materials in parts by weight: Rehmannia glutinosa 2-6 parts by weight, Cornus officinalis 2-6 parts by weight, Angelica sinensis 2-6 parts by weight Parts, Radix Paeoniae Alba 2~6 parts by weight, Epimedium 2~6 parts by weight, Salvia miltiorrhiza 1~3 parts by weight. The present invention also provides the preparation method of the above-mentioned traditional Chinese medicine composition, which can be prepared into technical solutions of tablets, capsules, pills, granules, soft capsules and oral liquid preparations.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating premature ovarian failure and its preparation method and application. technical background [0002] Premature Ovarian Failure (POF) refers to a disease characterized by amenorrhea, infertility, estrogen deficiency and gonadotropin elevation caused by some reasons in women before the age of 40. There are no oocytes or blasts in the follicles of patients, but they do not respond to gonadotropins, showing low estrogen levels and elevated gonadotropin levels. Clinically, the patient manifests as amenorrhea, infertility, and also has menopause-like symptoms such as flushing, sweating, mood swings, leucorrhea reduction, low libido, dry genitals, genitals and secondary sexual characteristics, which affect the quality of life of the patient . [0003] Modern medicine believes that the etiology of this disease is compli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P15/08
Inventor 萧伟王振中刘涛尚强孙永城章晨峰邹燕萍李淼
Owner JIANGSU KANION PHARMA CO LTD
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