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A pharmaceutical composition and the application thereof in the preparation of medicine for the treatment of cerebrovascular diseases

A technology for cerebrovascular disease and composition, which is applied in the field of preparation of drugs for the treatment of cerebrovascular disease, can solve the problems of abnormal liver function, unknown degree, thrombocytopenia and disseminated intravascular coagulation, etc., to reduce the effective dose, Low toxicity, effect of increasing therapeutic effect

Active Publication Date: 2012-04-18
NANJING SIMCERE DONGYUAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3-Methyl-1-phenyl-2-pyrazolin-5-one clinical dosage for adults is 60mg / d (mg / day), studies have found that it has certain side effects, such as acute renal failure of unknown degree, hepatic Adverse reactions such as dysfunction, thrombocytopenia and disseminated intravascular coagulation

Method used

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  • A pharmaceutical composition and the application thereof in the preparation of medicine for the treatment of cerebrovascular diseases
  • A pharmaceutical composition and the application thereof in the preparation of medicine for the treatment of cerebrovascular diseases
  • A pharmaceutical composition and the application thereof in the preparation of medicine for the treatment of cerebrovascular diseases

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Experimental program
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Effect test

Embodiment 1

[0020] Get Edaravone 2g (gram), add in the propylene glycol solution of 200g, stir and make it dissolve completely, slowly add water for injection and make it dissolve and reach 1000ml (milliliter), to obtain final product.

Embodiment 2

[0022] Take 2g of synthetic borneol, add to 200g of propylene glycol solution, stir to dissolve completely, slowly add water for injection to dissolve to 1000ml, to obtain.

Embodiment 3

[0024] Take 2g of natural borneol, add to 200g of propylene glycol solution, stir to dissolve completely, slowly add water for injection to dissolve to 1000ml, to obtain.

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Abstract

A pharmaceutical composition comprises 3-methyl -1-phenyl-2-pyrazolin-5-one and borneol, and can be used to prepare the medicine for treating cerebrovascular diseases.

Description

[0001] This application was submitted to the Chinese Patent Office on March 4, 2008, the application number is 200810020387.1, and the title of the invention is "a composition containing 3-methyl-1-phenyl-2-pyrazolin-5-one" The priority of the Chinese patent application of , the entire content of which is incorporated in this application by reference. technical field [0002] The invention relates to a pharmaceutical composition and its application in the preparation of medicines for treating cerebrovascular diseases. Background technique [0003] Cerebrovascular disease is a group of diseases that seriously endanger human health, and has become one of the important causes of human disability and death. [0004] Cerebrovascular disease (CVD for short) refers to brain lesions caused by abnormalities in cerebrovascular vessels. Stroke generally refers to acute cerebrovascular disease. [0005] Cerebrovascular diseases can be simply divided into two categories, one is ischemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4152A61K31/045A61P9/00A61P9/10
CPCA61K31/045C07D231/22A61K31/4152A61P43/00A61P9/00A61P9/10
Inventor 殷晓进杨士豹李晓强江征和健张安元黄鑫
Owner NANJING SIMCERE DONGYUAN PHARM CO LTD
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