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Cherokee rose leaf extract and application thereof in preparing medicine capable of curing burn and scald

An extract, the technology of golden cherry leaf, applied in the field of medicine, can solve the problem of no golden cherry leaf extract, etc., and achieve the effect of simple preparation method and low cost

Inactive Publication Date: 2011-11-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report that the leaf extract of Rosa japonica is used to prepare medicine for treating burns and scalds

Method used

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  • Cherokee rose leaf extract and application thereof in preparing medicine capable of curing burn and scald
  • Cherokee rose leaf extract and application thereof in preparing medicine capable of curing burn and scald
  • Cherokee rose leaf extract and application thereof in preparing medicine capable of curing burn and scald

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of Golden Cherry Leaf Extract

[0020] (1) prepare golden cherry leaf extract

[0021] Take 2 kg of golden cherry leaves [leaf of Rosa laevigata Michx.], soak overnight with 8 times the volume of 70% ethanol aqueous solution, heat and reflux extraction 3 times as usual, each time for 2 hours, combine the extracts, concentrate under reduced pressure until alcohol-free Taste, get the extract;

[0022] (2) Prepare the crude product of the extract

[0023] Dilute the above-mentioned golden cherry leaf extract with water and then filter to remove the precipitate. The filtrate is absorbed by D101 type macroporous resin, the amount of resin is 5kg, the impurities are washed away with water and 20% ethanol aqueous solution respectively, and then eluted with 10000ml 70% ethanol aqueous solution, collected and washed. The liquid was removed, the solvent was recovered under reduced pressure, and the crude product of the extract of the golden cherry leaf was...

Embodiment 2

[0026] Example 2 Preparation of Golden Cherry Leaf Extract

[0027] The preparation of the extract of the leaves of the golden cherry and the crude product of the leaf of the golden cherry is the same as that in Example 1.

[0028] During purification, extract crude product suspension of Rosa japonica leaf extract sequentially with equal volumes of ethyl acetate and n-butanol for 4 times respectively, combine extracts, recover solvent under reduced pressure, and obtain 45 g of extract.

Embodiment 3

[0029] Example 3 Healing test of golden cherry leaf extract on wounds of scalded rats

[0030] Take 30 SD rats, male or female, body weight 275-300g, provided by the Animal Center of Second Military Medical University, and randomly divided into 3 groups, namely blank control group, positive control group and golden cherry leaf extract treatment group, each group 10 Only. The positive drug is silver sulfadiazine (provided by Shanghai Changhai Hospital, the same below), which is widely used clinically to treat burns and scalds. Wound 20cm 2 , the skin was whitish, blisters appeared, and the pathological examination witnessed a model of deep second-degree burns. After debridement, silver sulfadiazine was applied to the wounds of the positive control group, golden cherry leaf extract was applied to the wounds of the treatment group, once a day, and the wounds of the blank control group were not treated for a total of 24 days. Observation indicators: The wound healing rate and w...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to a cherokee rose leaf extract and application thereof in preparing medicine capable of curing burn and scald. By a rat wound healing test, a Pseudomonas aeruginosa infection mice in vivo protection test and an anti-inflammatory test, the healing action on burn and scald by the cherokee rose leaf extract is observed. Results show that the cherokee rose leaf extract has high healing rate to burn and scald wound surface, can obviously inhibit Pseudomonas aeruginosa infection, can obviously inhibit mice ear dwelling actionand has no obvious difference with positive sulphonamide sulfadiazine silver (SD-Ag), and thus the cherokee rose leaf extract can be used for preparing medicines capable of curing burn and scald. Thecherokee rose leaf extract has simple preparation method and low cost and provides a new medicine resource for curing burn and scald.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to an extract obtained from the leaves of the traditional Chinese medicine Rosa chinensis and its application in the preparation of medicines for treating burns and scalds. Background technique [0002] Golden cherry leaf is the tender leaf of Rosa laevigata Michx. It is widely distributed in China, mainly in East China, Central South, Southwest and other regions. Golden cherry leaf is a commonly used traditional Chinese medicine among the people. It is one of the main components of the ancient prescription "A Twist of Gold in the Army", and it is mainly used to treat bleeding from gold sores. "Meddong Materia Medica" records "Treatment of soup and burns: golden cherry leaves are dried as the powder, mixed with sesame oil and applied to the affected area, and lame nail powder is added when it is about to heal." Modern pharmacological research proves that the fruit of Fructus Rosa ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/738A61P17/02A61K127/00
Inventor 沈阳林厚文曾娜朴淑娟胥静李萍陈万生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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