Protection effect of light-harvesting chromoprotein of algae on lens epithelial cells

Abstract

The invention belongs to the field of biological medicaments, and relates to a protection effect of a light-harvesting chromoprotein, namely, phycocyanin of algae on lens epithelial cells. The phycocyanin can obviously inhibit the reduction of the survival ratio of the lens epithelial cells and the increment of the content of reactive oxygen species (ROS) and malonaldehyde (MDA) caused by sodium selenite, and also can obviously inhibit the structure damage and the cell apoptosis of the lens epithelial cells caused by the sodium selenite; and therefore, the phycocyanin has a remarkable protection effect on the lens epithelial cells.

Description

technical field The invention relates to the field of biopharmaceuticals, in particular to the protective effect of a light-harvesting pigment protein of algae, that is, phycocyanin, on lens epithelial cells. Background technique Epidemiological and experimental studies have shown that non-congenital cataracts can be induced by various stress factors, such as ultraviolet radiation, oxidation, abnormal calcium metabolism, diabetes, and selenium. Although cataracts are the result of a combination of factors, oxidative stress is a common mechanism for their formation. Lens epithelial cell (lens epithelial cell, LEC) is the most active part of lens metabolism, and is responsible for the growth, differentiation and damage repair of the lens. out of the lens fiber cells and produce crystallin, which acts as a barrier between the lens and the outside world. The special location and function of LECs make them vulnerable to oxidative attack, causing oxidative damage. Once the cell...

AI Technical Summary

Problems solved by technology

Phycocyanin has a wide range of activities, including anti-cancer, anti-oxidation, and treatment of cerebral ischemic injury. However, there are no research reports and applications on the protective effect of phycocyanin on lens epithelial cells.

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