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Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof

A composition and drug technology, applied in the field of drugs, to achieve the effects of protecting nerve cells, reducing the volume of cerebral infarction, and controllable quality

Inactive Publication Date: 2011-04-27
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature report on the combined use of effective parts of Astragalus, Salvia Miltiorrhiza, and Chuanxiong in the treatment of stroke.

Method used

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  • Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof
  • Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof
  • Pharmaceutical composite for treating cerebral stroke, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 medicine of the present invention:

[0028] a. Astragalus decoction pieces are extracted with 30% ethanol, the filtrate is passed through a macroporous resin column, eluted with 30% ethanol, and the ethanol is recovered to obtain total saponins of Astragalus;

[0029] B, the preparation of Danshen ethanol extract: Danshen decoction pieces are heated and extracted with 8 times of water, and the extract is passed through a macroporous resin column (D 101 ), eluted with 50% ethanol, reclaimed ethanol, and obtained salvia miltiorrhiza phenolic acid; dregs were recovered and extracted with 95% ethanol, recovered ethanol, obtained salvia miltiorrhiza ketone extract, mixed salvia miltiorrhiza total phenolic acid and salvia miltiorrhiza total ketone extract, obtained Danshen alcohol extract;

[0030] c, the decoction pieces of Chuanxiong are extracted with 80% ethanol solvent, and the solvent is recovered to obtain Chuanxiong oil;

[0031]d. Th...

Embodiment 2

[0032] The preparation of embodiment 2 medicines of the present invention

[0033] a. Astragalus decoction pieces are extracted with 60% ethanol, the filtrate is passed through a macroporous resin column, eluted with 70% ethanol, and the ethanol is recovered to obtain total saponins of Astragalus;

[0034] b. Preparation of the alcoholic extract of Salvia miltiorrhiza: extract by heating the decoction pieces of Salvia miltiorrhiza with 15 times of water, pass the extract through a macroporous resin column, elute with 90% ethanol, recover the ethanol, and obtain the total phenolic acid of Salvia miltiorrhiza; recover and extract the dregs with absolute ethanol, recovering ethanol to obtain the total ketone extract of salvia miltiorrhiza, mixing the total phenolic acids of salvia miltiorrhiza with the total ketone extract of salvia miltiorrhiza to obtain the ethanol extract of salvia miltiorrhiza;

[0035] c, the decoction pieces of Chuanxiong are extracted with absolute ethanol...

Embodiment 3

[0037] Embodiment 3 preparation of medicine of the present invention

[0038] Take 6 kg of total astragalus saponins prepared in Example 1, 2.5 kg of alcoholic extract of Salvia miltiorrhiza and 3 kg of Chuanxiong oil, mix them, and prepare tablets according to the method in Example 1.

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PUM

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Abstract

The invention provides a pharmaceutical composite for treating cerebral stroke, which is prepared from the following ingredients in portion by weight: 1-50 portions of astragalosides, 1-50 portions of salvia miltiorrhiza extract and 0.5-30 portions of ligusticum chuanxiong oil. The invention further provides a medicine prepared from the active pharmaceutical ingredients of astragalosides, salvia miltiorrhiza extract and ligusticum chuanxiong oil. The medicine, due to the adoption of middle cerebral artery occlusion model (MCAO model) and the application of modern histopathology, flow cytometry and molecular biotechnology, has the effect of reducing cerebral infarction volume, protecting nerve cell, inhibiting apoptosis after cerebral ischaemia and blocking inflammatory reaction in ischemic infarction area. Through experiment, the result shows that, due to the compatibility of three ingredients, the medicine has the advantages of obvious synergism, definite efficacy and controllable quality, thereby clinically providing a new medicine for treating cerebral stroke.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cerebral apoplexy, which belongs to the field of medicine. Background technique [0002] Cerebrovascular disease is one of the main diseases that seriously endanger human life and health in the world today, and it is a common and frequently-occurring disease in our country. Stroke is a serious manifestation of various cerebrovascular diseases, with high disability rate and high mortality rate. Stroke has always been the main cause of death in China. The average age-standardized incidence rate of acute stroke events in the 25-74 age group is 270 / 100,000 males and 161 / 100,000 females, and the average age-standardized mortality rate is 89 / 100,000 males and 61 / 10 females million, the average age-standardized case fatality rate was 33% for men and 38% for women. It not only seriously threatens the lives of patients and affects their quality of life, but also brings heavy burdens to familie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10A61P25/00
Inventor 陈卫银严铸云祝彼得刘福友冉宁晶金硕果余芳谢文
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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