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Intelligent bending double-gel for visual detection of glucose in urine, method for preparing same and application thereof

A curved and intelligent technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of cumbersome methods and high costs, achieve low cost, convenient operation, and realize the effect of visual detection of urine sugar

Inactive Publication Date: 2010-06-09
HAIAN ZHONGSHAN SYNTHETIC FIBER +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problems of cumbersome methods and high costs in the prior art, the present invention provides an intelligent curved double glue for visual detection of urine sugar and its preparation method and application, which have the advantages of high sensitivity, convenience, and low price

Method used

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  • Intelligent bending double-gel for visual detection of glucose in urine, method for preparing same and application thereof
  • Intelligent bending double-gel for visual detection of glucose in urine, method for preparing same and application thereof
  • Intelligent bending double-gel for visual detection of glucose in urine, method for preparing same and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of intelligent bending double glue for visual detection of urine sugar, the intelligent bending double glue is composed of a layer of sensitive hydrogel film and a layer of non-sensitive hydrogel film, wherein the sensitive elements in the sensitive hydrogel are able to combine Molecules of glucose, such as boronic acid derivatives, concanavalin, glucose transporter.

[0026] The preparation method of the intelligent curved double glue for visual detection of urine sugar comprises the following steps:

[0027] The first step, the preparation of sensitive hydrogel film: the monomer of hydrogel, cross-linking agent, sensitive element, initiator, molar ratio is 100-10: 1-0.1: 10-1: 1-0.1 Proportion Dissolve in water to a weight-volume ratio of 4-30% to water, and polymerize to form a sensitive hydrogel film;

[0028] The second step, the preparation of non-sensitive hydrogel film: the monomer of hydrogel, cross-linking agent, initiator are dissolved in water in the...

Embodiment 2

[0036] The steps to prepare the standard spectrum for the semi-quantitative visual detection of urine sugar liquid with different concentrations are as follows:

[0037] The first step is to accurately weigh and prepare a group of glucose solutions with different concentrations;

[0038] In the second step, put the smart bending double glue for visual detection of urine sugar stored in pure water into the above-prepared solution, shake for 10 minutes, take pictures and record the degree of bending, as shown in the attached figure 1 As shown, as a standard map for the semi-quantitative visual detection of different concentrations of urine sugar solutions,

[0039] In the third step, put the washed smart bending double glue in the liquid to be tested, and observe the change of its bending degree, such as figure 2 As shown, when the concentration of urine sugar in the liquid to be tested is different, the bending degree of the smart bending double glue will also be different, a...

Embodiment 3

[0041] The sensitive element is made of boric acid derivatives for the visual detection of urine sugar with intelligent bending double glue, and the steps are as follows:

[0042] The first step, preparation of a sensitive hydrogel membrane containing boric acid derivatives: acrylamide, methylene acrylamide, 3-acrylamide-phenylboronic acid, ammonium persulfate in a molar ratio of 30:0.9:10:0.1 Proportion Dissolved in water to a weight-to-volume ratio of 7.5% to water, polymerized to form a sensitive hydrogel film with a thickness of 160 μm;

[0043] The second step, the preparation of non-sensitive hydrogel film: acrylamide, methylene acrylamide, ammonium persulfate, the molar ratio is 30:0.9:0.1, to the weight volume ratio of water is 7.5%, polymerized to form a thick 160μm non-sensitive hydrogel film;

[0044] In the third step, the sensitive hydrogel film obtained in the first step and the non-sensitive hydrogel film obtained in the second step are bonded together to form a ...

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Abstract

The invention discloses intelligent bending double-gel for visual detection of glucose in urine, a method for preparing the same and application thereof and relates to hydrogel and a method for preparing the same. The hydrogel is formed by bonding a layer of sensitive hydrogel and a layer of non-sensitive hydrogel together. The preparation method comprises the following steps of: dissolving monomers of hydrogel, a crosslinking agent, sensitive elements and an initiator in water in a molar ratio of 100-10:1-0.1:10-1:1-0.1 until the weight-to-volume ratio is 4 to 30 percent, and performing polymerization of the mixed solution to form the sensitive hydrogel; dissolving monomers of hydrogel, a crosslinking agent and an initiator in water in a molar ratio of 100-10:1-0.1:10-0.1 until the weight-to-volume ratio is 4 to 30 percent, and performing polymerization of the mixed solution to form the non-sensitive hydrogel; and bonding the sensitive hydrogel obtained by the step 1 and the non-sensitive hydrogel obtained by the step 2 together to form the intelligent bending double-gel for visual detection of glucose in urine. The intelligent bending double-gel can be suitably used for the non-traumatic household visual detection of glucose in urine.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a hydrogel suitable for non-invasive family urine sugar visual detection, a preparation method thereof and an application in urine sugar visual detection. Background technique [0002] For normal people, the glucose concentration in the blood remains at a relatively stable level. When the blood passes through the kidneys, the kidneys can prevent glucose from being filtered out and excreted into the urine, so the urine sugar is generally negative. However, the blood sugar of diabetic patients rises significantly. When the blood sugar rises to a certain level and the kidneys can no longer block the filtration of glucose from it, the glucose in the urine will become positive. [0003] In recent years, easy-to-learn blood glucose meters have become increasingly popular. In many urban families, patients themselves can perform blood glucose testing at home. It is not as difficult as it used to be for di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/493C08F220/56
Inventor 董健陈庆丰钱卫平
Owner HAIAN ZHONGSHAN SYNTHETIC FIBER
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