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Surface grafting modified polyurethane medical catheter and preparation method thereof

A surface graft modification, medical catheter technology, applied in catheters, coatings and other directions, can solve the problems that no one has proposed is effective and safe, shedding, and the increase in hydrophilicity and lubricity is not obvious, so as to improve biological Compatibility and anticoagulant, improving hydrophilicity and lubricity

Active Publication Date: 2012-11-07
珠海福尼亚医疗设备有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Their research shows that with the increase of PVP content in the semi-IPN structure, the hydrophilicity and lubricity of the catheter material increase, but when the PVP content increases to a certain amount, the trend of increasing hydrophilicity and lubricity is not obvious
In addition, the increase of PVP content may also cause the precipitation of PVP. Although PVP is an excellent biomedical material, it is still not expected to fall off during use.
[0010] However, for the antibacterial and anti-infection properties of polyurethane catheters, no one has proposed a practical, effective and safe technical means so far.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Pretreatment of polyurethane medical catheters: Soak polyurethane (PU) medical catheters of appropriate length in a mixed solvent of ethanol and deionized water with a volume ratio of 1:1 for 3 hours, remove the dirt on the surface of the catheters, and take them out with deionized pure After fully rinsing with water, dry it naturally or put it in a vacuum drying oven to dry, and weigh until constant weight.

[0023] (2) UV irradiation graft polymerization of polyurethane medical catheter: soak the cleaned polyurethane medical catheter in an ethanol solution with a NVP monomer concentration of 30vol.%. After 180s, take it out and put it into a quartz glass tube, and simultaneously Irgacure907 is used as photoinitiator, benzophenone is used as photosensitizer, and ultraviolet light is irradiated at room temperature for 30 minutes; then the catheter is taken out, rinsed with a large amount of water and soaked in water for 24 hours, and the water is changed continuously...

Embodiment 2

[0028] (1) Pretreatment of polyurethane medical catheters: Soak polyurethane (PU) medical catheters of appropriate length in a mixed solvent of ethanol and deionized water with a volume ratio of 1:1 for 3 hours, remove the dirt on the surface of the catheters, and take them out with deionized pure After fully rinsing with water, dry it naturally or put it in a vacuum drying oven to dry to constant weight.

[0029] (2) UV irradiation graft polymerization of polyurethane medical catheter: Soak the cleaned polyurethane medical catheter in pure NVP, take it out and put it into a quartz glass tube after 30s, and use Irgacure907 as photoinitiator at the same time, use diphenyl Use ketone as a photosensitizer, and irradiate with ultraviolet light for 30 minutes at room temperature; then take out the catheter, rinse it with a large amount of water and soak it in water for 24 hours, and change the water constantly to remove unreacted monomers and polyvinylpyrrolidone homopolymers. Dry na...

Embodiment 3

[0034] (1) Pretreatment of polyurethane medical catheters: Soak polyurethane (PU) medical catheters of appropriate length in a mixed solvent of ethanol and deionized water with a volume ratio of 1:1 for 3 hours, remove the dirt on the surface of the catheters, and take them out with deionized pure After fully rinsing with water, dry it naturally or put it in a vacuum drying oven to dry to constant weight.

[0035] (2) UV irradiation graft polymerization of polyurethane medical catheter: soak the cleaned polyurethane medical catheter in an ethanol solution with a NVP monomer concentration of 50vol.%. After 180s, take it out and put it into a quartz glass tube, and simultaneously Irgacure907 is used as photoinitiator, benzophenone is used as photosensitizer, and ultraviolet light is irradiated at room temperature for 10 minutes; then the catheter is taken out, rinsed with a large amount of water and soaked in water for 24 hours, and the water is changed continuously to remove unr...

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Abstract

The invention relates to a surface grafting modified polyurethane medical catheter and a preparation method thereof. A polyvinyl pyrrolidone (PVP) modified layer (i.e. PU-g-PVP structure) is formed on the surface of a polyurethane (PU) medical catheter through ultraviolet irradiation grafting polymerization reaction and then a PU-g-PVP-I structure is prepared through the complex reaction of the PU-g-PVP and iodine (I). PVP-I (povidone iodine) is bonded with the surface of the PU catheter by chemical bonds so that the hydrophily and the lubricating property of PVP-I can be increased and the biocompatibility and the anticoagulant property of materials can be improved, whereas the PVP-I also enables the polyurethane medical catheter to have anti-infection property and sterilizing ability. The invention solves the defect that the traditional polyurethane medical catheter does not have the anti-infection property or the sterilizing ability, and achieves the best grafting rate and grafting density through controlling the factors of monomer concentration of N-vinyl pyrrolidone, irradiation time and the like.

Description

【Technical field】 [0001] The invention relates to a medical device and a production process thereof, in particular to a surface graft-modified polyurethane medical catheter and a preparation method thereof. 【Background technique】 [0002] In recent years, with the rapid development and interpenetration of polymer science, medicine and biology, biomedical polymer materials have become functional materials with broad research and application prospects. At present, the research and development of biomedical polymer materials has become an important field to promote the progress of modern medicine and improve the clinical level. As a blood-compatible material in contact with the human blood environment, it has always been the focus of research. Polyurethane material has good wear resistance, elasticity, biocompatibility and anticoagulant property, and is one of the most widely studied anticoagulant medical polymer materials. [0003] Polyurethane is a general term for polymers...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/06A61L29/14
Inventor 祝方明瞿雪芬李志云左传为郑雄斌丁侃贤
Owner 珠海福尼亚医疗设备有限公司
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