Compound drug for curing colds and preparation technology thereof

Abstract

The invention relates to a compound drug for curing colds and a preparation technology thereof. The compound drug consists of active components of Ibuprofen, pseudoephedrinehydrochloride, chlorphenamine maleate with effective doses and proper amount of pharmaceutic adjuvants, which is characterized by preparing lbuprofen with a partial effective dose and pseudoephedrinehydrochloride with an effective dose into a sustained-release preparation; preparing ibuprofen with a residual effective dose and chlorphenamine maleate with an effective dose into an immediate-release preparation; and preparing the sustained-release preparation and the immediate-release preparation into various drug preparations according to conventional methods. The invention adopts the sustained-release technology and the immediate-release technology, effectively controls absorption and use of the three different drug active components in vivo, enables the blood concentration of the three drug active components to achieve effective curative concentration and coincidence in decreasing time, thus enhancing the pesticide effect of the compound drug in the invention cooperatively and improving bioavailability of the compound drug in the invention.

Description

technical field [0001] The invention relates to a compound medicine for treating colds and a preparation process thereof. Background technique [0002] Ibuprofen is an effective prostaglandin synthase inhibitor with antipyretic, analgesic and anti-inflammatory effects; it is almost insoluble in water, but easily soluble in sodium hydroxide or sodium carbonate test solution. It is easy to absorb after oral administration and rectal absorption after administration. Tmax (representing the time taken from taking the medicine to the peak blood concentration) is about 0.92±0.33h. When the dosage is 200mg, the blood concentration is 22μg / ml~27μg / ml; When the dosage is 23μg / ml~45μg / ml; when the dosage is 600mg, it is 43μg / ml~57μg / ml. Half-life T after one dose 1 / 2 Generally 1.82h. [0003] Pseudoephedrine hydrochloride has selective vasoconstriction, eliminates congestion and swelling of nasopharyngeal mucosa, relieves symptoms such as nasal congestion, is easily dissolved in wat...

AI Technical Summary

Problems solved by technology

However, due to the differences in the absorption and half-life of the above three drugs, the plasma concentration curves of the three drugs are quite different, and the therapeutic concentration cannot be reached at the same or similar time and maintained for a certain period of time. If taken frequently, it may cause drugs with long half-lives not to be eliminated in time, thus accumulating in the body, resulting in some side effects; drugs with short half-lives cannot maintain effective blood drug concentration and fail to achieve therapeutic effect

[0006] At present, the compound drug containing the active ingredients of the above three drugs has been listed in the United States. It is a common preparation made by conventional traditional preparation technology. The absorption and half-life of each drug are different, the release of active ingredients of each drug is uneven, and the drug effect is not ideal