Cell culture system

Abstract

The invention relates to a cell culture system comprising a three-dimensional biocompatible skeleton structure and biocompatible nanoparticles, to a method for cultivating cells, to the preparation ofcells, cell products and tissue and to the targeted production of cells or cell products and tissue using a cell culture system of this type.

Description

technical field The invention relates to a cell culture system comprising a three-dimensional biocompatible framework (dreidimensional biokompatible Gerüststruktur) and nanoparticles (Nanopartikel). The invention also relates to a method for preparing such a cell culture system and a method for culturing cells using said cell culture system. Background technique Cells in vivo are surrounded by a complex, dynamic microenvironment consisting in particular of extracellular matrix (Matrix, ECM), growth factors (Wachstumsfaktoren), cytokines (Cytokinen) and neighboring cells (benachbarten Zellen). The extracellular matrix exists in a total of four basic tissue types, namely epithelial, muscular, neural, and connective and supportive tissues. In addition to their function as a kind of supporting framework, which has long been considered their main function, the ECM is primarily used for interactive signal exchange through the cell's transmembrane receptors. Due to this form of c...

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Problems solved by technology

Thus, the active agent is directly available to the cells, however, a disadvantage is that the active agent may be used up quickly and its concentration cannot be adjusted in a controlled manner to the respective differentiation and growth stages of the cultured cells

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