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Tripterine and tripterine derivatives for treating cancer, inflammation and central nervous system diseases

A technology of tripterine and its derivatives, applied to nervous system diseases, non-central analgesics, anti-inflammatory agents, etc.

Inactive Publication Date: 2010-01-13
朱永亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tripteryglide is a protein kinase and topoase inhibitor

Method used

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  • Tripterine and tripterine derivatives for treating cancer, inflammation and central nervous system diseases
  • Tripterine and tripterine derivatives for treating cancer, inflammation and central nervous system diseases
  • Tripterine and tripterine derivatives for treating cancer, inflammation and central nervous system diseases

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Embodiment 1

[0023] Tripteryglide was used in experiments on mice. Model mouse L1210 was obtained from implanted leukemia cells. It is an important model animal for testing whether compounds have anticancer activity. Screening based on the model mouse L1210 provided a variety of small molecule compounds approved by the FDA for the treatment of leukemia or lymphoma. CDF1 mice grew tumors very quickly after being implanted with leukemia cells L1210. In this experiment, tripteryglide was dissolved in alcohol and saline solution and injected intravenously into mice at 0.5 mg / kg animal. Compared with the control group, the survival rate of the treatment group was significantly improved.

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Abstract

The invention discloses novel tripterine derivatives. Tripterine and the tripterine derivatives can inhibit tumor cell growth. The invention discloses a method for treating cancer, inflammation and central nervous system diseases by the tripterine and the tripterine derivatives.

Description

technical field [0001] The present invention relates to several new tripteryne derivatives, new applications of tripteryne and derivatives thereof, especially the application in treating cancer, inflammation and central nervous system diseases. Background technique [0002] Tripterygium wilfordii was isolated and identified from Tripterygium Wilfordii Hook□f. Studies in recent years have successively found that Tripterygium wilfordii has anti-inflammatory, anti-immune, anti-fertility, and antibacterial activities. However, there are few research reports on the anti-cancer effects of Tripterygium wilfordii. A new study found that Celastrol (Celastrol, a triterpene ketone) is an inhibitor of cancer cell apoptosis by controlling the proteasome of cancer cells. Experiments have proved that it has effectively inhibited the proliferation of prostate cancer in nude mice . Chinese patent CN101091713 discloses tripteryglide capsules for the prevention and treatment of nerve injury...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/56A61K31/704A61P35/00A61P29/00A61P25/00
Inventor 朱永亮
Owner 朱永亮
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