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Preparation, medicinal preparation and use of dihydromyricetrin

A technology of dihydromyricetin and plants, which is applied in the field of medicine and can solve the problems of prevention and treatment of senile dementia that have not been reported

Inactive Publication Date: 2009-07-08
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report that it has the effect

Method used

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  • Preparation, medicinal preparation and use of dihydromyricetrin
  • Preparation, medicinal preparation and use of dihydromyricetrin
  • Preparation, medicinal preparation and use of dihydromyricetrin

Examples

Experimental program
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Effect test

Embodiment 1

[0048] Example 1 , the preparation of dihydromyricetin:

[0049] Medicinal material 1kg, reflux extraction 2-3 times with 50-80% ethanol (preferably 70% ethanol) 8 times, extract 1-3 hours each time, decolorize with activated carbon of 0.5% (w / v) of extract, filter, filtrate Through the pre-treated D101 or AB-8 macroporous resin, the effluent is concentrated and recovered to 500ml of ethanol, placed for crystallization (4-10°C), centrifuged, precipitated and crystallized with ethanol-water for 2-3 times to obtain dihydrogen Myricetin crystals (content 96.7%). Dihydromyricetin crystals were separated and purified on a C-18 reverse-phase column (atmospheric pressure), using chloroform-methanol as the eluent, collecting dihydromyricetin fractions, combined after TLC identification, and part of the solvent was evaporated to obtain The single component dihydromyricetin with a purity of over 98% (content 98.9%).

[0050] Embodiment 1 (capsule)

[0051] Dihydromyricetin 100g, app...

Embodiment 2

[0052] Embodiment 2 (tablet)

[0053] Dihydromyricetin raw material 100g, appropriate amount of medicinal starch, appropriate amount of dextrin, mix uniformly, granulate, dry, granulate, dry, add appropriate amount of lubricant, compress into tablets, and make 1000 tablets, to get ready. 1 tablet each time, 3 times a day.

Embodiment 3

[0054] Embodiment 3 (dropping pill)

[0055] Weigh 30g of polyethylene glycol 4000, melt it on a water bath, add 10g of dihydromyricetin raw material, stir evenly, pour it into the insulation tube, adjust the constant temperature device, and make the medicine drop into the cooled liquid at 80-90°C In paraffin, after dripping, pour the pills into the filter paper to absorb the paraffin oil, make 1000 capsules, and get final product. 10 capsules each time, 3 times a day.

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Abstract

The invention discloses a method for extracting dihydromyricetin from stem leaves of Ampelopsis sinica(Miq.)W.T.Wang of Ampelopsis Michx and stem leaves of Ampelopsis grossedetata(Hand- Mazz)W.T.wang, a medicine preparation and new medical application. The dihydromyricetin can be applied to prevention and treatment of senile dementia. A prepared medicine can either contain the dihydromyricetin only, or be a composition containing the dihydromyricetin, and can be pharmaceutical preparations, such as tablets, capsules, granules, and dripping pills or injections.

Description

technical field [0001] The invention relates to a new method for extracting and preparing medical raw material dihydromyricetin from plants of the genus Snake Grape in the family Vitis genus, a drug preparation and a new medical application thereof, belonging to the technical field of medicine. Background technique [0002] The plants of the genus Snake Grape and Snake Grape mainly contain dihydromyricetin and myricetin. It has been reported in the literature that the extraction of dihydromyricetin mainly includes decocting or ultrasonically extracting plants of the Vitaceae family through various solvents (water or organic solvents), Concentrate, then dissolve in hot water, filter while hot, and separate the filtrate directly by chromatography; soak the medicinal materials in a solvent, filter, and carry out microwave radiation treatment, combine the filtrate, heat and extract in a water bath, filter while hot, dissolve the filtrate in hot water, and use cold water The recr...

Claims

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Application Information

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IPC IPC(8): C07D311/40C07D311/32A61K31/352A61P25/28
Inventor 赫玉芳南敏伦初洪波赵全成
Owner 赵全成
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