Treating obesity with muscarinic receptor m1 antagonists
An antagonist, a psychological technique, applied in the field of treatment of depression, can solve the problems of no treatment of mental illness, pirenzepine failed to produce behavioral effects, etc.
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[0154] Antidepressant effect: The antidepressant effect of compounds was evaluated using the rat tail suspension method. The method was described by Steru et al., (Stem L, et al., Psychopharmacol 85:367-70, 1985; Stem L, et al., Prog Neuro-Psychopharmacol & Biol Psychiat 11:659-71, 1987) and later by Crowley et al. A variant of the human method (Crowley JJ, et al., Pharmacol Biochem Beh 78(2):269-74, 2004) was adapted. Seven to eight week old (25-35 g) male CD-1 mice were housed for one week prior to testing. Mice (n=8-10 / dose group) were dosed intraperitoneally (ip) or orally (po) with the drug under study and returned to their cages for appropriate pretreatment intervals (45- 60 minutes). Using adhesive tape, suspend the mouse from the tensiometer by its tail. Based on the intensity of movement recorded by the tensiometer, activity in the following 6 minutes was scored by computer: 1) immobility, 2) avoidance behavior or 3) severe avoidance behavior. Total immobility is ...
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