Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amikacin desorbed solution concentration method using nano filtration technique

A technology of amikacin and analytical solution, which is applied in the field of concentration of amikacin analytical solution, can solve the problems of low rejection rate of monovalent inorganic salts, reduce energy consumption, shorten reaction time, and increase product yield and quality effects

Active Publication Date: 2009-06-17
山东安信制药有限公司
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nanofiltration membranes can intercept low-molecular-weight organics such as sugars and high-priced inorganic salts (MgSO 4 etc.), but the rejection rate of monovalent inorganic salts is low (only 10% to 80%), and it has a considerable permeability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amikacin desorbed solution concentration method using nano filtration technique
  • Amikacin desorbed solution concentration method using nano filtration technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The feed liquid used in this embodiment is amikacin analysis solution, pH 11.5-12.

[0036] A method for concentrating amikacin analysis solution, the steps are as follows:

[0037] 1. Pre-filtration and purification

[0038] At room temperature, the inlet pressure of the pre-filter system is controlled at 1MPa, and the outlet pressure is 0.8MPa. The material liquid (amikacin analysis solution) is transported into the pre-filter system through the material transfer pump, and the filtered amikacin enters the cleaning system. The liquid storage tank, while the suspended particles are intercepted, and then proceed to the next step of nanofiltration concentration.

[0039] 2. Nano-membrane concentration

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for concentrating Amikacin desorbed solution by nanofiltration technology. The method comprises: firstly, prefiltrating and purifying the Amikacin desorbing solution; and then, feeding the Amikacin desorbing solution into a charging bucket, and concentrating the solution by adopting the nanofiltration technology, wherein the membrane flux of a nanofiltration membrane is between 20 and 40 L / m2h, the pH value of the Amikacin desorbed solution is between 10 and 12, the temperature is between 0 and 40 DEG C, and the pressure at the inlet of the charging bucket is between 0.2 and 2 MPa. The method for concentrating Amikacin desorbed solution overcomes the disadvantages of the prior process including declining product degradation, quality and yield, and ensures that concentration yield can reach 98 percent; moreover, the product has ideal appearance and obviously improved quality after crystallization, and production period is reduced at the same time.

Description

technical field [0001] The invention relates to the application of nanofiltration membrane technology in the field of antibiotics, especially the application in the concentration of amikacin analysis solution. technical background [0002] Amikacin, having the structure shown in formula I, is a semi-synthetic derivative of kanamycin A and is a broad-spectrum antibiotic. [0003] [0004] Amikacin I [0005] There is no method for concentrating the amikacin analysis solution in existing documents and patents. The method commonly used in production is thin film evaporation. Due to the high energy consumption of the thin film evaporation method and the long heating time, the heat-sensitive amikacin product is partially destroyed, the yield is reduced, and the product quality is affected. Thereby be unfavorable for industrialized production. [0006] With the development of membrane technology, the nanofiltration membrane that appeared in the 1980s filled the gap between ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/14C07H15/234
Inventor 李保勇樊长莹宿乾贞饶光辉孙政军蔡成伟
Owner 山东安信制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com