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Chinese medicine granule containing red paeonia extract and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations without active ingredients, etc., which can solve the problems of lack of immediate release characteristics, low drug loading of granules, and unsightly appearance and other problems, to achieve the effect of good physical properties, small specific surface area, and short dissolution time limit

Inactive Publication Date: 2012-06-06
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The preparation of active ingredient of the present invention:

[0058] Take: 20.49g of Danshen, 6.83g of Chuanxiong, 6.83g of Radix Paeoniae Rubra, 12.29g of Cassia Seed, 13.66g of Hawthorn and 8.20g of Leech;

[0059] The above-mentioned leeches and 0.68g of Ligusticum Chuanxiong were crushed into powder, and the particle size was 130 μm; take red peony root, cassia seed, and hawthorn and add water to decoct twice: the first time was 8 times the amount of water for 2 hours, and the second time was 6 times the amount of water. double the amount of water for 1 hour; combine the decoction, concentrate, add ethanol to make it precipitate, recover the extract that the ethanol is concentrated to a relative density of 1.10, and set aside; then take Danshen and the remaining 6.15g Chuanxiong, and reflux with ethanol for 2 For the first time, it was 7 times the amount of ethanol for 2 hours, and for the second time it was 6 times the amount of ethanol, and the time was 1.5 hou...

Embodiment 2

[0063] Preparation of active components of the present invention: take 23.9g of Danshen, 6.07g of Chuanxiong, 3.41g of Radix Paeoniae Rubra, 34.15g of Semen Cassiae, 0.68g of Hawthorn and 0.09g of Leech.

[0064] Grind the above leech and 0.3g Chuanxiong into powder, and the particle size is 140 μm; take red peony root, cassia seed, and hawthorn and add water to decoct twice: the first time is 6 times the amount of water for 1 hour, and the second time is 9 times the amount of water. Double the amount of water for 2 hours; combine the decoction, concentrate, add ethanol to make it precipitate, reclaim the extract that the ethanol is concentrated to a relative density of 1.20, and set aside; then take Salvia miltiorrhiza and the remaining 5.77g of Chuanxiong, and reflux with ethanol for 2 For the first time, it was 8 times the amount of ethanol for 2 hours, and for the second time it was 6 times the amount of ethanol for 1.5 hours; filter, reclaim ethanol, make it a relative den...

Embodiment 3

[0068] The preparation of active ingredient of the present invention: take 15g of salvia miltiorrhiza, 10g of Chuanxiong, 10g of red peony, 18g of cassia seed, 15g of hawthorn and 0.3g of leech.

[0069] Grind the above-mentioned leech and 0.70g of Rhizoma Chuanxiong into powder, and its particle size is 150 μm; take red peony root, cassia seed, and hawthorn and add water to decoct 3 times: the first time is 10 times the amount of water for 2 hours, and the second and third times each 9 times the amount of water, each for 1 hour; combine the decoction, concentrate, add ethanol to make it precipitate, recover the extract that the ethanol is concentrated to a relative density of 1.30, and set aside; then take Salvia miltiorrhiza and the remaining 9.3g of Rhizoma Chuanxiong, Reflux 3 times with ethanol, the first time is 8 times the amount of ethanol for 2 hours, and the second time. 6 times the amount of ethanol for each of the three times, and the time is 1.5 hours each; filter...

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Abstract

The invention provides a traditional Chinese medicine granular preparation containing red paeonia extractive and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by traditional Chinese medicine extractive and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g / ml. The spheroidized particles of the invention has low single dose, is convenient in use, can be served as intermediate products of capsules, and also can be used for developing a traditional Chinese medicine controlled release preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing Radix Paeoniae Rubra extract and a preparation method thereof. Background technique [0002] Stroke is a common and frequently-occurring disease that seriously endangers human health, and its disability and mortality are very high. According to pertinent data report: suffer from apoplexy patient, its death rate accounts for more than 62% of this patient group, reaches up to 80%, has caused misery to patient and family, has caused heavy burden to society. Therefore, it is particularly important for the prevention of stroke. [0003] Apoplexy syndrome is a clinical syndrome closely related to apoplexy. It is more common in middle-aged and older people, and the main clinical manifestations are recurrent vertigo, numbness on one side of the body, limpness, astringent speech and syncope. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/40A61K36/734A61K36/71A61K36/537A61K36/482A61K36/236A61K35/62A61P9/10A61K47/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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