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Chinese medicine granule containing salvia root extract and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations without active ingredients, etc., which can solve the problems of lack of immediate release characteristics, low drug loading of granules, and unsightly appearance and other problems, to achieve the effect of good physical properties, small specific surface area, and short dissolution time limit

Active Publication Date: 2012-03-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Extraction of extract: Take Danshen and Panax notoginseng, add water and decoct 3 times, decoct liquid, filter, concentrate the filtrate, alcohol precipitation, let stand for 24 hours, filter, recover ethanol, concentrate into a thick paste to a relative density of 1.33- 1.35 (50-60°C) for later use. After taking borneol and cyclodextrin or PVP for inclusion, mix the inclusion solution and extract evenly, and set aside;

[0046] Preparation of masterbatch: Take dextrin and starch in a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and the starch is added with water to prepare starch slurry (15%) Spray it in as a slurry, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, use the remaining 35% dextrin from the powder gun Sprinkle with fine powder of starch to make...

Embodiment 2

[0049] Extraction of extract: 1800g of salvia miltiorrhiza, 400g of notoginseng and 3g of borneol for later use; decocting of salvia miltiorrhiza and notoginseng with water 5 times, combined decoction, filtered, concentrated filtrate, added 5 times the amount of 80% ethanol, stood for 12 hours, filtered After that, ethanol is recovered, and the filtrate is concentrated to a thick paste 1 with a relative density of 1.05 to 1.15 at 80° C.; the crushed borneol is added to the thick paste 1 to prepare the traditional Chinese medicine extract of the present invention.

[0050] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as a base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the ...

Embodiment 3

[0053] Extraction of extract: Salvia miltiorrhiza 1500g, Sanqi 70g and borneol 25g for later use; Salvia miltiorrhiza and Panax notoginseng add water to decoct twice, combine the decoction, filter, concentrate the filtrate, add 2 times the amount of 90% ethanol, let stand for 36 hours, filter After that, ethanol is recovered, and the filtrate is concentrated to a thick paste 1 with a relative density of 1.05 to 1.35 under the condition of 30° C.; borneol dissolved in an appropriate amount of ethanol is added to the thick paste 1 to prepare the Chinese medicine extract of the present invention.

[0054] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200 mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve o...

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PUM

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Abstract

The invention provides a traditional Chinese medicine granular preparation with radix salviae miltiorrhizae extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing salvia miltiorrhiza extract and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary heart disease is the abbreviation of coronary heart disease. It is a disease with high morbidity and mortality and seriously endangers the health of human beings, so it is called "the first killer of human beings". Angina pectoris is a clinical syndrome caused by coronary artery blood supply insufficiency, myocardial acute, transient ischemia and hypoxia. It often occurs when you are tired, full of food, col...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/40A61K36/537A61K36/258A61K31/045A61P9/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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