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New use of sodium-ion channel blocker compound in clearing biosome endotoxin

A sodium ion channel and compound technology, applied in the new application field of sodium ion channel blocker compounds to remove toxins from living organisms

Inactive Publication Date: 2009-05-06
江苏宏锦天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In the prior art, there is no reference to 1. Amino perhydroquinazoline compounds and biguanide hydrogenated purine ring compounds and their derivatives in the present invention. Research on various harmful components (toxins)

Method used

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  • New use of sodium-ion channel blocker compound in clearing biosome endotoxin
  • New use of sodium-ion channel blocker compound in clearing biosome endotoxin
  • New use of sodium-ion channel blocker compound in clearing biosome endotoxin

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0155] Example 1, take tetrodotoxin (TTX), content (95-99%) 10mg, use citric acid 150μg, adjust the solution of pH=5.0-7.0 with sodium citrate, calculate by containing 10ug per 2ml, make 1000 injections Liquid, tested by HPLC, after the content is up to standard, filled, sterilized, meet the medical hygiene standards or veterinary standards, can be used, referred to as: Tetrodotoxin Salt A.

example 2

[0156] Example 2, get deoxytetrodotoxin, content (85-98%) 1mg, use oxalic acid 150μg, adjust the solution of PH=5.0-7.0 with sodium oxalate, calculate by containing 10ug per 2ml, make 1000 injections, use PLC After the test, the content is qualified, filled and sterilized, and it can be used after meeting the medical hygiene standards or veterinary standards. It is called Tetrodotoxin B for short.

example 3

[0157] Example 3, get tetrodotoxin acid, content (85-95%) 1mg, use 150 μ g of malic acid, be mixed with the solution of PH=5.0-7.0, calculate by containing 10ug per 2ml, make 1000 injections, detect with PLC, After the content is qualified, it can be filled and sterilized, and it can be used after meeting the medical hygiene standards or veterinary standards. It is referred to as Tetrodotoxin C.

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PUM

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Abstract

The invention relates to a sodium ion channel blocker compound, a derivative thereof and the new application of medical salts and esters thereof in removing the vivotoxin and biotoxin, in particular to the new application of the compound in removing various harmful chemical components remained in human bodies and organisms. The sodium ion channel blocker mainly refers to: 1. an amino perhydro-quinazoline compound and pharmaceutically acceptable salts and esters thereof; and 2. a bi-guanidino hydrogenated purine ring compound and pharmaceutically acceptable salts and esters thereof. The harmful components in the human bodies and organisms removed by the invention are as follows: (1) the residue of various antibiotics; (2) the residue of various pesticides; (3) the residue of various exogenous hormones; and (4) various inorganic and organic chemical matters harmful to the human bodies.

Description

technical field [0001] The invention relates to a medicine for removing harmful toxins in organisms by sodium ion channel blocker compounds and medicinal salts and esters thereof [0002] Application field Background technique [0003] The sodium ion channel blocker compound and pharmaceutically acceptable salts or esters thereof of the present invention refer to 1, amino perhydroquinazoline small molecule chemical compounds extracted from natural aquatic organisms represented by tetrodotoxin or artificially synthesized Element. Its molecular structural formula: [0004] [0005] Tetrodotoxin plane structure (I) Tetrodotoxin three-dimensional structure (II) [0006] Where: R 1 =R 2 =R 4 =R 5 =OH,R 3 =CH 2 OH; Tetrodotoxin [0007] R 1 =R 3 =R 4 =R 5 =OH,R 2 =CH 2 OH; [0008] Tetrodotoxin molecular formula: C 11 h 17 N 3 o 8 , molecular weight 319.27. [0009] 2. Biguanide-based hydropurine ring compounds extracted from natural aquatic orga...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P43/00A61P39/02
Inventor 邱芳龙杨辉
Owner 江苏宏锦天药业有限公司
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