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Implantable sensors and implantable pumps and anti-scarring agents

A sensor, scar technology, applied in the direction of organic active ingredients, peptide/protein ingredients, tetracycline active ingredients, etc., can solve problems such as inaccurate readings

Inactive Publication Date: 2009-04-29
ANGIOTECH INT AG (CH)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the sensor is detecting conditions inside the sac and those conditions do not coincide with conditions outside the sac (as they usually do), it will produce inaccurate readings

Method used

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  • Implantable sensors and implantable pumps and anti-scarring agents
  • Implantable sensors and implantable pumps and anti-scarring agents
  • Implantable sensors and implantable pumps and anti-scarring agents

Examples

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example

[0591] The present invention provides agents (eg, chemotherapeutic agents) that can be delivered from a composition and that have potent antimicrobial activity at very low doses. A variety of anti-infective agents can be used in combination with the compositions of the present invention. Suitable anti-infective agents can be readily determined based on the assay provided in Example 52. Discussed in more detail below are representative examples of some agents that may be used: (A) anthracyclines (e.g., doxorubicin and mitoxantrone), (B) fluoropyrimidines (e.g., 5-FU ), (C) folate antagonists (eg, methotrexate), (D) podophyllotoxins (eg, etoposide), (E) camptothecin, (F) hydroxyurea, and (G) platinum compounds (eg, cisplatin).

[0592] (A). Anthracyclines

[0593] Anthracyclines have the following general structures, where the R groups can be different organic groups:

[0594]

[0595] According to U.S. Patent No. 5,594,158, suitable R groups are as follows: R 1 for CH...

Embodiment 1

[1235] Parylene coating

[1236] Washing is performed by immersing the metal part of the housing of the device (eg, MiniMed 2007 Implantable Insulin Pump, Medtronic, Inc.) in HPLC grade isopropanol. Use a parylene coater (for example, PDS 2010 LABCOATER 2 from Cookson Electronics) and di-p-xylylene (PARYLENE N) or dichloro-bis-p-xylylene ( PARYLENE D) (both available from Specialty Coating Systems, Indianapolis, IN) was used as the coating feed material to deposit a parylene primer layer (approximately 1 to 10 um) on clean equipment.

Embodiment 2

[1238] Paclitaxel Coating - Partial Coating

[1239] Paclitaxel solutions were prepared by dissolving paclitaxel (5 mg, 10 mg, 50 mg, 100 mg, 200 mg and 500 mg) in 5 ml HPLC grade THF. The coated portion of the parylene-coated device (as prepared, eg, in Example 1) was immersed in the paclitaxel / THF solution. After the selected incubation time, the devices were removed from the solution and dried in a forced air oven (50°C). The device was then dried overnight in a vacuum oven. The amount of paclitaxel and the incubation time used for each solution were varied so that the amount of paclitaxel coated on the device was 0.06 μg / mm 2 to 10μg / mm 2 (μg Paclitaxel / mm 2 device, which was placed in THF / paclitaxel solution and then coated with paclitaxel). The time the device is kept in the paclitaxel / THF solution can be varied, with longer soak times generally providing more adsorption of paclitaxel to the device. In another example, paclitaxel was replaced with one of the follow...

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Abstract

Pump contacting with tissue, sensor and scar formation preventing agent are combined in use to prevent scar from forming. Otherwise, while all the pump and sensor are implanted into an animal body, scar is possible to be formed.

Description

Background of the invention [0001] field of invention [0002] The present invention relates generally to implantable sensors, drug delivery devices and drug delivery pumps, and more particularly to compositions and methods of making and using such devices to render them resistant to inflammatory and fibrous scar tissue overgrowth . [0003] Description of related fields [0004] Implantable drug delivery devices and pumps are devices that provide long-term, site-specific release of therapeutic agents to treat a variety of medical conditions. When localized drug action is desired (i.e., the disorder affects only a specific area) or when systemic delivery of the agent is inefficient or ineffective and results in toxicity, severe side effects, inactivation of the drug before it reaches the target tissue, poor symptom / disease control, and / or Drug delivery implants and pumps are commonly used in drug addiction. Implantable pumps can also deliver systemic drug levels long-te...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K31/7012A61K31/70A61K31/65A61K31/045A61K33/14A61K38/19A61K38/20A61K38/18A61K38/24
Inventor W·L·亨特D·M·格雷维特P·M·托莱克斯A·迈蒂
Owner ANGIOTECH INT AG (CH)
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