Method for treating aortic stenosis with non-antibacterial tetracycline formulations

Abstract

The present invention is for a method for treating aortic stenosis in a mammal in need thereof. The method comprises administering an effective amount of a non-antibacterial tetracycline formulation, to the mammal.

Description

Background technique [0001] The aortic valve connects the heart's lower left chamber (ventricle) to the body's largest artery, the aorta. Aortic stenosis, also known as aortic stenosis, is a condition in which the valve of the artery becomes narrow. This narrowing prevents the aortic valve from opening fully, which prevents blood from flowing from the heart into the aorta and on to the rest of the body. As a result, the heart pumps less blood with each beat and less blood reaches all parts of the body. [0002] Aortic stenosis can be mild, moderate, or severe. Symptoms may include fatigue, dizziness, chest pain or pressure, fainting, shortness of breath, palpitations, heart murmurs, or swelling of the ankles or feet. If left untreated, aortic stenosis can lead to serious heart problems, including heart failure and sudden death. [0003] Treatment options for aortic stenosis include surgery and / or medication. Rarely, the opening of the aortic valve can be widened using a t...

AI Technical Summary

Problems solved by technology

[0016] However, alteration of the basic ring system or substitution of substituents at one or more positions at positions 4 and 10-12a often results in synthetic tetracyclines with significantly reduced antimicrobial activity or practically no antimicrobial activity

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