Method for preparing ozagrel sodium crystal
A technology for sodium ozagrel and crystallization, which is applied in the field of crystallization technology of the medicinal compound ozagrel sodium, can solve the problems of high content of "related substances", low yield, lack of fine filtration, and crystal cultivation, etc. The effect of low content, high yield and high purity
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Embodiment 1
[0010] Add the crude sodium ozagrel solution into 99% ethanol, heat to 80°C to dissolve it, add activated carbon for 30 minutes, filter while it is hot, continue to pass the filtrate through a 0.45 micron membrane, collect the filtrate, and then continue to filter the filtrate Raise the temperature to 80°C, slowly cool down to about 45°C, control the temperature at 40-43°C and keep it warm for 2.5 hours, then continue to cool down to 4-10°C and keep it warm for 2 hours, then slowly cool down, cool and crystallize, and finally collect the crystals. Rate: 90.8%, content: 100.3%.
Embodiment 2
[0012] Add the crude sodium ozagrel solution into 80% ethanol, heat to 80°C to dissolve it, add activated carbon for decolorization for 30 minutes, filter while it is hot, continue to pass the filtrate through a 0.45 micron membrane, collect the filtrate, and then continue to filter the filtrate Raise the temperature to 80°C, slowly cool down to about 45°C, control the temperature at 30-45°C and keep it warm for 2.5 hours, then continue to cool down to 4-10°C and keep it warm for 2 hours, then slowly cool down, cool and crystallize, and finally collect the crystals. Rate: 90.9%, content: 100.1%.
Embodiment 3
[0014] Add the crude sodium ozagrel solution into 95% ethanol, heat to 60°C to dissolve it, add activated carbon for 30 minutes, filter while it is hot, continue to pass the filtrate through a 0.45 micron membrane, collect the filtrate, and then continue to filter the filtrate Raise the temperature to 60°C, slowly cool down to about 45°C, control the temperature at 40-43°C and keep it warm for 2.5 hours, then continue to cool down to 4-10°C and keep it warm for 2 hours, then slowly cool down, cool and crystallize, and finally collect the crystals. Rate: 91.3%, content: 99.9%.
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