Medicament composition for damp-heat type icterohepatitis and preparation method thereof

A technology for jaundice hepatitis and composition, which is applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of multiple side effects, poor treatment effect of complications, lack of rationality of formulation, etc., and achieves scientific, reasonable and significant formulation. Efficacy, receptive effect

Active Publication Date: 2009-01-28
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many medicines for the treatment of such diseases. Although western medicines are effective quickly, they have many side effects, and the treatment effect on complications is very poor.
According to the syndrome differentiation of traditional Chinese medicine for such diseases, the use of traditional Chinese medicine treatment can completely achieve the effect of treating both symptoms and root causes. Efficacy

Method used

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  • Medicament composition for damp-heat type icterohepatitis and preparation method thereof
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  • Medicament composition for damp-heat type icterohepatitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Radix Paeoniae Alba 75g Polygonum cuspidatum 75g

[0075] Money grass 225g Yuan Hu 45g

[0076] Rhizoma chinensis is crushed, add 12-15 times the amount of 60-80% ethanol to soak for 2-4 hours, reflux extraction 1-3 times, each time for 1-3 hours, after the ethanol is recovered from the medicinal solution, the reflux liquid of rhubarb root is obtained for use, and the dregs Add water to decoct with the other 3 flavors for 1-3 times, each time for 1-3 hours, combine the decoction, concentrate to a relative density of 1.10-1.30 (50-70°C), add 2-4 times the amount of 90-98% ethanol, Refrigerate and stand still for 12-48 hours, recover ethanol from the supernatant, combine with Yuanhu reflux liquid, concentrate to a relative density of 1.20-1.38 (50-70°C), add appropriate amount of auxiliary materials, and prepare various preparations for clinical application. Including granules, capsules, tablets, oral liquids, soft capsules, dropping pills, dispersible tablets, and effer...

Embodiment 2

[0078] Radix Paeoniae Alba 75g Polygonum cuspidatum 75g

[0079] Money grass 225g Yuan Hu 45g

[0080] The above four flavors, Yuan Hu broken, add 14 times the amount of 70% ethanol to soak for 3 hours, reflux extraction twice, 2 hours each time, after the ethanol is recovered from the medicinal liquid, the Yuan Hu reflux liquid is obtained for later use, and the dregs and the remaining 3 flavors are decocted in water Boil twice, 2 hours each time, combine the decoction, concentrate to a relative density of 1.10-1.20 (60°C), add 3 times the amount of 95% ethanol, refrigerate and stand for 24 hours, recover the ethanol from the supernatant, and reflux with Yuanhu Liquids are combined, concentrated to a relative density of 1.30-1.35 (60°C), and appropriate amount of excipients are added to prepare various preparations suitable for clinical application, including granules, capsules, tablets, oral liquids, soft capsules, dropping pills, Dispersible tablet, effervescent agent.

Embodiment 3

[0082] Radix Paeoniae Alba 75g Polygonum cuspidatum 75g

[0083] Money grass 225g Yuan Hu 45g

[0084] The above four flavors, Yuan Hu broken, add 14 times the amount of 70% ethanol to soak for 3 hours, reflux extraction twice, 2 hours each time, after the ethanol is recovered from the medicinal liquid, the Yuan Hu reflux liquid is obtained for later use, and the dregs and the remaining 3 flavors are decocted in water Boil twice, 2 hours each time, combine the decoction, concentrate to a relative density of 1.10-1.20 (60°C), add 3 times the amount of 95% ethanol, refrigerate and stand for 24 hours, recover the ethanol from the supernatant, and reflux with Yuanhu The liquids are combined and concentrated to a relative density of 1.30-1.35 (60°C). Take 1 part of clear paste, 1.5 parts of dextrin, and 2.5 parts of sucrose, granulate, dry, and granulate to make 380g.

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Abstract

The invention provides a medicine combination for clearing away heat, promoting diuresis, activating blood circulation and dissolving stasis and a preparation method thereof; the medicine combination is composed of red paeony root, giant knotweed, desmodium and rhizoma corydalis; the preparation method is as follows: rhizoma corydalis is pulverized and added with 60-80 percent ethanol which is 12-15 times of rhizoma corydalis to be soaked for 2-4 hours, and reflux extraction is carried out for 1-3 times, 1-3h per time; after ethanol is recovered, liquid medicine is obtained ready for use, and dregs and other three medicines are added with water and decocted for 1-3 times, 1-3h per time; decoction is merged, concentrated to a relative density of 1.10-1.30 (50-70 DEG C), added with 90-98 percent ethanol which is 2-4 times of the concentrated decoction and then stands still at refrigeration condition for 12-48h; after the ethanol is recovered, supernatant fluid and ethanol reflux of rhizoma corydalis are merged, concentrated to a relative density of 1.20-1.38(50-70 DEG C), added with a proper quantity of excipients so as to prepare various preparations for clinical application. The medicine combination can be used for treating damp-heat icterohepatitis.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating hepatitis and a preparation method thereof, in particular to a traditional Chinese medicine composition for icteric hepatitis caused by damp-heat and blood stasis and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Hepatitis is the name of a disease in modern medicine. According to its clinical characteristics, it belongs to the category of "hypochondriac pain" and "jaundice" in traditional Chinese medicine. Throughout the onset of this disease, it is mostly due to unclean diet, evil poison invading, and damage to the liver. It is the mother of qi, when qi moves, blood moves, and when qi stagnates, blood stasis, liver qi stagnates for a long time, qi movement is not smooth, overwhelms spleen soil, spleen fails to move, water and dampness stop internally, heat is transformed over time, damp heat accumulates in th...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/00A61K9/16A61P1/16A61P31/14
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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