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Solid preparation containing ibuprofen and tranexamic acid

A technology of tranexamic acid and preparation, which can be applied in the directions of anti-inflammatory agent, pill delivery, non-central analgesic agent, etc., can solve the problems of small analgesic effect and the like

Inactive Publication Date: 2012-05-23
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since ibuprofen has side effects such as gastrointestinal disturbances, and its analgesic effect is small, it has been studied in combination with various drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 900 g of ibuprofen (manufactured by Yonezawa Hamari: trade name Japanese Pharmacopoeia Ibuprofen), tranexamic acid 1499.4 g (manufactured by Daiichi Sankyo Profile: trade name Japanese Pharmacopoeia Tranexamic Acid), anhydrous citric acid 106.2 g (manufactured by Komatsuya Chemical: brand name Japanese Pharmacopoeia anhydrous citric acid), carmellose calcium 360 g (manufactured by Gotoku Pharmaceutical: brand name ECG505), lactose hydrate 1897.2 g (brand name lactose 200M made by DMV INTERNATIONAL) After throwing into a high-speed stirring granulator (manufactured by Fukae Industry: FS-10 type) and mixing, 466 g of purified water was added and then kneaded. The granulated material was put into a fluidized bed dryer (manufactured by Floint Industries: Model FLO-5) and dried, and then sized by a granulator (manufactured by Okada Seiko: ND-10). 4762.8 g of the whole granules and 97.2 g of magnesium stearate were put into a mixer (manufactured by Kotobuki: PM50 t...

Embodiment 2

[0065] Example 2 Tablets were obtained in the same manner as in Example 1, except that anhydrous citric acid was replaced with malic acid (manufactured by Kawasaki Chemical Industries: trade name malic acid food additive 40M). Test example 2 The tablet obtained in Example 2 was subjected to the same test as in Test Example 1 with the shelf life set at one month. As a result, the expansion ratio after storage at 40° C. for one month was 0.1%, and a remarkable expansion suppressing effect was confirmed. In addition, it was also confirmed that the tablet of the present invention (Example 2) was a stable tablet without cracking or chipping even after storage.

Embodiment 3

[0066] Example 3 Tablets were obtained in the same manner as in Example 1, except that anhydrous citric acid was replaced with propyl gallate (manufactured by Wako Pure Pharmaceutical Industry: trade name propyl gallate).

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PUM

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Abstract

The invention provides a solid preparation restricted under high-temperature preserving condition and containing brufen as well as tranexamic acid. The solid preparation contains organic acid or ester or salt thereof.

Description

technical field [0001] The present invention relates to a solid preparation comprising ibuprofen and tranexamic acid whose swelling is inhibited under high-temperature storage conditions. Background technique [0002] Ibuprofen is widely used as a non-steroidal anti-inflammatory drug (NSAID), anti-inflammatory and analgesic for chronic joint rheumatism, joint pain and arthritis, neuralgia and neuritis, low back pain and other diseases and symptoms Effective, in addition to cold syndrome, acute bronchitis, acute exacerbation of chronic bronchitis anti-inflammatory and antipyretic, etc. are also effective. However, since ibuprofen has side effects such as gastrointestinal disturbances and has a small analgesic effect, a combination preparation with various drugs has been studied. [0003] For example, antipyretic analgesics in which ibuprofen is mixed with aniline derivative antipyretic analgesics such as busetin (see Patent Document 1), and preparations in which ibuprofen is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61K31/192A61K9/00A61K47/12A61P29/00
CPCA61K9/20A61K31/192A61K31/195A61K47/12
Inventor 薄井俊树下川达张川岛弘行
Owner KOWA CO LTD
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