Tumour target thermotherapy method based on metallic grain or its compound thermal chemical reaction

A technology of thermochemical reaction and metal particles, applied in medical science, heating surgical instruments, inorganic non-active ingredients, etc., can solve the problems of side effects of patients, high price, complex structure, etc., achieve reduced thermal damage, easy operation, and simplified instruments The effect of the design

Inactive Publication Date: 2008-07-16
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented inventive technique involves inserting an implant called nanosilver (silicon) inside cancer cells before they are taken out alive by surgery. When this treatment stops working properly, tiny holes form within them allowing blood vessels to flow freely throughout the body without causing any harm during healing process. These holes help release some energy stored in surrounding healthy areas when exposed to high temperatures. By adding these materials together afterward, the treated region becomes more sensitive to temperature changes than if just one was used alone. Overall, this new approach simplifies the operation and makes possible effective treatments against brain tumors caused by chemotherapies like temozolomide.

Problems solved by technology

Technologies aim towards developing new therapies like cancer immunomodulation techniques have emerged but they face challenges related to efficient delivery of therapeutic agents into specific areas while avoid harmful impacts caused by current technological solutions. Current approaches involve various types of radiation exposure, including X ray irradiation, ionizing radiation, and others, making them potentially dangerous and causing severe injury to both physicians and patients. Nanotoxins offer potential alternatives because they provide precise control over cellular functions through chemical reactions. They may achieve better efficacy than traditional ways of inducing destructiveness against diseased tissue, reducing risk and improving outcomes compared to conventional methods.

Method used

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  • Tumour target thermotherapy method based on metallic grain or its compound thermal chemical reaction
  • Tumour target thermotherapy method based on metallic grain or its compound thermal chemical reaction
  • Tumour target thermotherapy method based on metallic grain or its compound thermal chemical reaction

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Embodiment 1

[0050] Metal nanoparticles or their compounds can be selected from pure solid particles or solid oxide particles and their combinations, for example, in a mixture composed of sodium and other metals, the content of sodium can be 1-99%; the ratio of other metals is the same as Same thing. By examining the properties of metals such as sodium, potassium, magnesium, and calcium, it is found that the heat of reaction between sodium and water is sufficient to meet the requirements of hyperthermia. At the same time, the sodium ions produced by the reaction are the main ions in the intracellular and extracellular fluids, which can participate in the metabolism of water and ensure the safety of the body. Water, acid and alkali balance; Potassium reacts with water to generate a lot of heat, while potassium ions help maintain nerve health, maintain a normal heartbeat, and assist in normal muscle contraction. These two metals are particularly suitable for tumor hyperthermia. The size of ...

Embodiment 2

[0070] The solid delivery method provided by the present invention can be in the form of a disposable injection. The simple one-time injection can directly adhere the liposome-encapsulated micro-nano solid particles to the end of the injection, and after the insertion position of the guide hole is determined, it will be sent in by the stent. Among them, the material of the bracket can be made of plastic or metal, and the hollow design guides the gas generated by the reaction to discharge the treatment area. The bracket can be designed in a cylindrical shape with a length of 10 mm to 300 mm and an inner diameter of 0.2 mm to 5 mm, and can be made of stainless steel or plastic.

Embodiment 3

[0072] The delivery method provided by the invention can directly inhale solid particles with a straw, and the injection port is encapsulated with paraffin.

[0073] When in use, the paraffin can be melted by heating, and the amount of release can be controlled by squeezing the air above the straw, so that the solid particles can be delivered to the targeted tumor area. The straw has a length of 10 mm to 300 mm and an inner diameter of 0.2 mm to 5 mm, and can be made of plastic.

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Abstract

The invention relates to a tumor targeting hyperthermia method based on metal particles or thermochemical reaction of the compounds thereof. First, the tumor size and position are determined by a B-ultrasound, a CT or an nuclear magnetic resonance image; reactant to be used is determined according to the tumor size and position and is put into the a conveying cavity at the rear part of the stent of a syringe; under the guide of the imaging equipment, the skin that is in the position of the tumor is punctured, and the syringe is inserted into the targeting tissue of the tumor, then the reactant is injected inside the targeting tissue of the tumor; the reactant is micro nanometer metal and the compound thereof and can generate chemical heat to lead tumor tissue necrosis so as to reach the purpose of tumor tissue thermotherapy after combining with the DNA molecules of the human body. The tumor hyperthermia method is easy to carry out conformal treatment to the tumor of complex shape; the reactant is injected under room temperature, therefore the surrounding health tissue cannot be burnt during injecting; besides, the invention has the advantages of fast heatingup response speed, good treatment effect, low cost, convenient operation, etc.

Description

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Claims

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Application Information

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Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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