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Method for preparing natural silk functional dressings

A functional, silk technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problem of small direct adsorption, achieve the effect of repeated use and increase the adsorption of drugs

Inactive Publication Date: 2008-05-21
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the direct adsorption amount of silk to β-phenylacrylic acid is very small, only 0.073mg / g

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: A) Dissolve α-cyclodextrin in dimethyl sulfoxide at a weight ratio of 1:8; then add o-iodobenzoic acid at a molar ratio of 1:1 - Iodosobenzoic acid, reacted at 20°C for 20 hours, stirred, filtered off the insoluble matter, added an appropriate amount of acetone, precipitated a white solid, filtered, washed the obtained white solid with acetone, and freeze-dried to obtain cyclodextrin Monoaldehyde;

[0015] B) the silk fiber is put into the Na of 0.5% weight percentage concentration for 1: 50 by weight 2 CO 3 solution, boiled for 30 minutes to degumming;

[0016] C) The silk fiber after degumming is put into the acidic aqueous solution that pH value is 4 by weight ratio is 1: 30, is 1: 1 to add cyclodextrin monoaldehyde by the weight ratio of silk fiber and cyclodextrin monoaldehyde, stirs , react at 20°C for 1 hour;

[0017] D) Put the reducing agent sodium cyanoborohydride into the reaction solution according to the molar ratio of cyclodextrin monoaldehy...

Embodiment 2

[0019] Example 2, A) Dissolve β-cyclodextrin in dimethyl sulfoxide at a weight ratio of 1:10; then add o-iodobenzoic acid at a molar ratio of 1:1.6 - Iodosobenzoic acid, reacted at 30°C for 28 hours, stirred, filtered off the insoluble matter, added an appropriate amount of acetone, precipitated a white solid, filtered, washed the obtained white solid with acetone, and freeze-dried to obtain cyclodextrin Monoaldehyde;

[0020] B) the silk fiber is put into the Na of 0.5% weight percentage concentration for 1: 50 by weight 2 CO 3 solution, boiled for 30 minutes to degumming;

[0021] C) The silk fiber after degumming is put into the acidic aqueous solution that pH value is 7 by weight ratio 1: 50, adds cyclodextrin monoaldehyde by the weight ratio of silk fiber and cyclodextrin monoaldehyde as 1: 3, stirs , reacted at 30°C for 3 hours;

[0022] D) Put the reducing agent sodium cyanoborohydride into the reaction solution according to the molar ratio of cyclodextrin monoaldeh...

Embodiment 3

[0024] Example 3, A) Dissolve γ-cyclodextrin in dimethyl sulfoxide at a weight ratio of 1:8.8; then add o-iodobenzoic acid at a molar ratio of 1:1.3 - Iodosobenzoic acid, reacted at 25°C for 24 hours, stirred, filtered off the insoluble matter, added an appropriate amount of acetone, precipitated a white solid, filtered, washed the obtained white solid with acetone, and freeze-dried to obtain cyclodextrin Monoaldehyde;

[0025] B) the silk fiber is put into the Na of 0.5% weight percentage concentration for 1: 50 by weight 2 CO 3 solution, boiled for 30 minutes to degumming;

[0026] C) The silk fiber after degumming is put into the acidic aqueous solution that pH value is 6 by weight ratio is 1: 40, is 1: 2 by the weight ratio of silk fiber and cyclodextrin monoaldehyde, adds cyclodextrin monoaldehyde, stirs , reacted at 25°C for 2 hours;

[0027] D) Put the reducing agent sodium cyanoborohydride into the reaction solution according to the molar ratio of cyclodextrin mono...

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Abstract

The present invention relates to a preparation method of silk functional dressing, which is to graft cyclodextrin to silk fiber through chemical bonds, and then use β-phenylacrylic acid as a guest molecule to prepare silk functional dressing products; it can be used for development Anti-infection and anti-inflammation functional dressing products; it uses the three-dimensional chiral cavity microenvironment of cyclodextrin as a storage space for drugs, which can greatly increase the drug adsorption capacity of the material, and its adsorption of β-phenylacrylic acid The amount can reach 2.178mg / g.

Description

technical field [0001] The invention relates to a preparation method of a silk functional dressing, which belongs to the technical field of preparation methods of textiles. Background technique [0002] Silk is a natural protein with a unique molecular structure, excellent mechanical properties, excellent moisture absorption and anti-microbial properties, good biocompatibility with the human body, and many irreplaceable advantages of other materials. The materials used have important market prospects. The National Key Basic Research Development Program (973 Program) is also organizing forces to carry out research in this area. [0003] β-phenylacrylic acid, its natural products should exist in styrax and cinnamon oil, is a kind of substance with rich sources and safe use. Recent studies have found that it has anti-microbial, anti-inflammatory, anti-platelet aggregation effects and a wide range of anti-body Tumor activity, can inhibit the proliferation of a variety of tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/32A61L15/28
Inventor 胡智文温会涛万军民陈文兴
Owner ZHEJIANG SCI-TECH UNIV
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