Implantable artificial substituting unit

An artificial and cell-based technology, applied in the field of biomedicine, can solve problems that have not yet been reported as an alternative unit

Inactive Publication Date: 2008-03-26
FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Therefore, it is necessary to study artificial replacement units with compens

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  • Implantable artificial substituting unit
  • Implantable artificial substituting unit

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Embodiment Construction

[0020] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0021] The artificial replacement unit of the present invention is equivalent to an artificial organ analog, wherein the scaffold needs to be designed so that the substitute has a specific shape and volume, and provides physical and nutritional support; active cells need to be designed inside the unit and in the support so that the substitute has Specific function and lifespan, and there should be cells with the potential to differentiate into vascular endothelial cells, which can grow in the replacement unit and enter the surrounding tissue cells to form a capillary network that communicates with the recipient's body circulation.

[0022] Based on the above design ideas, the structure of the artificial replacement unit of the present invention is shown in Figure 1, including: an outer enclosure 1, a hollow support 2 placed in the outer enclos...

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Abstract

The present invention discloses an artificial substitute unit. It can be implanted into human body and can be used as temporary substitute for retaining specific tissue function. Said substitute includes a peripheral body, a hollow supporting frame placed in said peripheral body interior, intracavity filled cells placed in the inner cavity of said supporting frame and filler and functional cells and nutrient matrix body placed between said supporting frame and peripheral body, on the wall surfaces of the described supporting frame and peripheral body several through microporous channels are uniformly distributed, and the described intracavity filled cells can be induced and differentiated into endothelial tissue cells, and the extracavity filled cells can be changed according to the application direction of artificial substitute unit, and can be induced and differentiated into required functional cells, such as liver cells, pancreatic island beta cells, adrenal cortex cells and fat cells, etc.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to an artificial organ with specific functions or a structure called a replacement unit, which can be implanted into a human body as a temporary substitute for maintaining specific tissue functions. Background technique [0002] Organ transplantation is an important treatment for organ failure. Take the treatment of liver disease as an example. The liver is one of the most complex organs in the human body. There are more than 300 million liver disease patients in the world. Orthotopic liver transplantation is the only mature and effective treatment for liver failure and congenital liver metabolic diseases. However, the lack of donor livers is a major problem faced by countries all over the world. Although several methods of partial liver transplantation, such as piggyback, split, and living donor, have been developed in recent years to maximize the use of the donor liver, they st...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61F2/02A61L27/00
Inventor 裴雪涛王韫芳粱峰张磊林峰岳慧敏南雪颜永年管利东
Owner FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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