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Nebulizer formulation

A technology of nebulizers and preparations, which is used in diseases, treatment of COPD, asthma and other diseases related to reversible airway obstruction. Ampoules include the field of nebulizer preparations, which can solve the problems of not providing enough treatment, reducing patient compliance, and hindering applications. , achieve the effect of reducing distraction time, improving compliance and reducing spray time

Inactive Publication Date: 2007-12-19
BREATH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can lead to a further decrease in patient compliance, as underdosing will not provide adequate therapy, preventing further use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A bulk nebulizer formulation was prepared having the following composition:

[0068] Component Amount / Concentration

[0069] Levalbuterol 0.625mg / ml

[0070] Ipratropium 0.25mg / ml

[0071] Sodium chloride solution (for injection) 9 mg / ml

[0072] Hydrochloric acid Adjust pH to 4.0

[0073] The formulation was loaded into 2 mL (extractable volume) twist-top plastic ampoules.

Embodiment 2

[0075] A bulk nebulizer formulation is prepared having the following composition:

[0076] Component Amount / Concentration

[0077] Levalbuterol 0.83mg / ml

[0078] Ipratropium 0.33mg / ml

[0079] Sodium chloride solution (for injection) 9 mg / ml

[0080] Hydrochloric acid Adjust pH to 4.0

[0081] The formulation was loaded into 1.5 mL (extractable volume) twist-top plastic ampoules.

[0082] Accordingly, the present invention provides nebulizer formulations and uses thereof.

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PUM

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Abstract

A nebulizer formulation contains levalbuterol and ipratropium in about 2ml or less of saline and is used for treatment of COPD and asthma and other airways diseases and disorders with increased patient compliance.

Description

Background of the invention [0001] The present invention relates to a nebulizer formulation, in particular to a nebulizer formulation and a method for treating diseases such as chronic obstructive pulmonary disease (COPD) and asthma using the nebulizer formulation. [0002] The nebulizer provides a means for the patient's airway to administer the drug while the patient is breathing at an approximately normal rate. It is especially useful in patients who, whether age or impairment or otherwise, are unable to inhale at the much higher rates required for administration via a metered dose inhaler or dry powder inhaler, and who, regardless of What is the reason for not coordinating the activation of the MDI with the breath inhaled by the patient. The nebulizer device produces a vapor containing drug particles that the patient inhales through a nozzle or mask attached to the nebulizer. Typically, nebulizers are used to deliver drugs to treat airway conditions such as asthma and CO...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/37A61K31/46A61P11/06A61K9/00A61K31/137
CPCA61K9/0078A61K31/137A61K31/46A61K31/37A61P11/00A61P11/06A61P43/00A61K2300/00
Inventor I·G·C·麦克阿弗P·E·塔什科
Owner BREATH
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