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Sugar-reducing medicine composition

A composition and technology of hypoglycemic drugs, applied in the field of medicine, can solve the problem that it is difficult to reach the level of hypoglycemic, and the research report on the combination of biguanide hypoglycemic drugs and thiazolidinedione hypoglycemic drugs B vitamins and three is not found. , can not reduce the harm of Hcy to diabetic patients and other problems

Inactive Publication Date: 2007-11-14
SHENZHEN AUSA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a small number of existing studies have focused on the relationship between biguanides (especially metformin) and homocysteine, and we have not found biguanides, thiazolidinediones, and B vitamins. Combined Research Reports
In fact, the combination of biguanide hypoglycemic drugs and thiazolidinedione hypoglycemic drugs cannot reduce the harm of Hcy to diabetic patients; the combination of biguanide hypoglycemic drugs and B vitamins is difficult to achieve the ideal hypoglycemic level

Method used

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  • Sugar-reducing medicine composition
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  • Sugar-reducing medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1 Preparation of compound metformin rosiglitazone folic acid (0.4mg) sheet (1000 sheet amount)

[0078] Formula: Metformin Hydrochloride 500g

[0079] Rosiglitazone 4g

[0080] Folic acid 0.4g

[0081] Starch 100g

[0082] Microcrystalline Cellulose 100g

[0083] Sodium carboxymethyl starch 75g

[0084] Low-substituted hydroxypropyl cellulose 75g

[0085] Proper amount of povidone ethanol solution

[0086] Magnesium Stearate 0.5%

[0087] Preparation method: crush the auxiliary materials through an 80-mesh sieve, and dry for later use. Take 500g of metformin hydrochloride, 4g of rosiglitazone, and 0.4g of folic acid and mix them uniformly according to the method of equal increase, and add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the prescription amount, and press Mix evenly by increasing the amount, use 5% povidone K29 / 30-95% e...

Embodiment 2～ Embodiment 7

[0088] Embodiment 2 to Embodiment 7 Preparation of metformin rosiglitazone folic acid tablets containing different content ratios

[0089] The preparation method is the same as in Example 1, and the granules obtained according to the formula shown in Table 1 are made into tablets.

Embodiment 8

[0090] Example 8 Prepare compound metformin rosiglitazone vitamin B12 (2mg) sheet (1000 sheet amount)

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Abstract

The present invention relates to a new-type hypoglycemic medicine composition. Said new-type hypoglycemic medicine composition contains biguanide hypoglycemic medicine or its medicinal salt with effective dose, thiazolidione hypoglycemic medicine or its medicinal salt with effective dose, vitamins B with effective dose and medicinal carrier or excipient. Said invention also provides the application of said medicine composition in preparation of medicine for preventing and / or curing diabetes and its complication.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing biguanide hypoglycemic drugs, thiazolidinedione hypoglycemic drugs and B vitamins, and the use of the composition in preparing drugs for treating and / or preventing diabetes. The invention belongs to the field of medicine. Background technique [0002] Diabetes mellitus is a metabolic disease of multiple etiologies characterized by chronic hyperglycemia accompanied by disturbances in carbohydrate, fat and protein metabolism due to defects in insulin secretion and / or action. Diabetes is currently a serious epidemic. In 2003, 194 million people worldwide had diabetes, ranging in age from 20 to 79 years. By 2025, this number may increase by 72% to 333 million, and approximately 80% of cases Will be distributed in poor industrial developing countries. my country is one of the three countries with the largest number of people with diabetes. On October 12, 2004, the Ministry of Health, the Mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/714A61K31/155A61K31/4436A61K31/525A61K31/51A61K31/4415A61K9/20A61K9/48A61P3/10
Inventor 王文艳秦献辉李华于多戴成祥徐希平
Owner SHENZHEN AUSA PHARMA
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