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Biologically-active adhesive articles and methods of manufacture

A technology of biologically active substances and products, applied in medical science, coatings, absorbent pads, etc., can solve the problems of reducing the effect of wound care products, affecting the physical properties of the PSA layer, reducing the adhesive strength of the PSA layer, etc.

Inactive Publication Date: 2007-07-25
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, bioactive substances applied to wound care articles generally affect the physical properties of the PSA layer
For example, coating a bioactive substance on a PSA layer can act as a plasticizer reducing the adhesive strength of the PSA layer and correspondingly reducing the effectiveness of the wound care product

Method used

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  • Biologically-active adhesive articles and methods of manufacture
  • Biologically-active adhesive articles and methods of manufacture
  • Biologically-active adhesive articles and methods of manufacture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] A mixture of 1.0% silver (I) oxide and 5.0% ammonium carbonate was heated to 60° C. and stirred until the silver (I) oxide was dissolved to prepare its aqueous solution. The fluid solution was ink-jet printed on the adhesive surface of Tegaderm using "XAARXJ128-200 print head" with 100% surface coverage. The print head is driven by 1.25kHz and 3.5V piezoelectric, with a printing resolution of 300×300dpi. The normal volume of the fluid solution drop thus produced is about 70 pL. The sample was then dried in an oven at 150°C for 10 minutes.

Embodiment 2

[0115] The fluid solution in Example 1 was ink-jet printed on the adhesive surface of Tegaderm with a surface coverage of 200% according to the ink-jet printing method described in Example 1 and dried.

Embodiment 3

[0117] The fluid solution in Example 1 was ink-jet printed on the adhesive surface of Tegaderm with 100% surface coverage according to the ink-jet printing method described in Example 1, but the coated sample was dried at room temperature (25°C) 24 hour.

[0118] Buying example 4

[0119] The fluid solution in Example 1 was ink-jet printed on the adhesive surface of Tegaderm HP with 100% surface coverage according to the ink-jet printing method described in Example 1 and dried.

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Abstract

The present invention is a method of coating an adhesive layer. The method includes non-contact depositing a fluid solution onto the adhesive layer and allowing the fluid solution to substantially dry, where the fluid solution comprising a biological active. The fluid solution exhibits a Hildebrand solubility parameter of at least about 3.7 MegaPascals<1 / 2> greater than a Hildebrand solubility parameter of the adhesive layer.

Description

Background of the invention [0001] Wound care products have a variety of designs, such as bandages and wound accessories, which are used to protect the wound from external environmental conditions during the treatment process. Pressure sensitive adhesive (PSA) layers are commonly used to attach wound care products to wounds on the skin of patients. Generally, the PSA layer is coated on the back substrate, where the back substrate can be a variety of materials, such as elastic films, foams, woven materials, non-woven materials or gauze. [0002] Generally, wounds can heal more effectively in a moist environment. However, such an environment also increases the risk of bacterial infection. To reduce the risk, many wound care products are designed to release bioactive substances such as antimicrobial agents to prevent or treat bacterial infections. [0003] In this way, by using the bioactive substance with the PSA layer, the wound care product can maintain contact with the wound site...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/58A61L15/48
CPCA61L2300/404A61L15/46A61L2300/202A61L15/58A61L2300/206A61L2300/104A61L2300/606A61L2300/106A61L2300/22A61L2300/11A61L15/48A61L15/585A61L2300/212
Inventor 卡罗琳·M·伊利塔洛杰弗里·H·托其马修·T·斯科尔茨普拉巴卡拉·S·拉奥斯蒂芬·E·克兰佩马克·J·亨德里克森彼得·T·埃利奥特斯科特·A·伯顿
Owner 3M INNOVATIVE PROPERTIES CO
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