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Agricultural bactericide containing camptothecin or camptothecin derivative and application thereof

An agricultural fungicide, camptothecin technology, applied in the direction of fungicides, biocides, chemicals for biological control, etc., can solve the problems of insoluble, low practicability and so on

Inactive Publication Date: 2010-01-13
YIFAN AGRI CHEM PLANT ZHEJIANG PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the above-mentioned alkaloids are all natural alkaloids, and are difficult to dissolve in water, especially camptothecin, the enforceability of this patent is relatively small
And the report that camptothecin or camptothecin derivative is applied in crop fungicide has never seen

Method used

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  • Agricultural bactericide containing camptothecin or camptothecin derivative and application thereof
  • Agricultural bactericide containing camptothecin or camptothecin derivative and application thereof
  • Agricultural bactericide containing camptothecin or camptothecin derivative and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1) Put 100L of ethanol into the reaction kettle or stirring tank, add 60L of calcium dodecylbenzene sulfonate, after stirring, add 40L of OP-10, mix well, that is, compound emulsifier, ready for use;

[0023] 2) Put 400L of dimethyl sulfoxide into another reactor or stirring tank, add 0.5kg of camptothecin with a purity of 90%, heat to 35°C and stir constantly, after the camptothecin is completely dissolved, add the above compound 20L of emulsifier, after stirring evenly, add 15L of JFC and 5L of azone, and stir evenly to obtain the final product.

Embodiment 2

[0025] 1) Put 100L of ethanol into the reaction kettle or stirring tank, add 60L of calcium dodecylbenzene sulfonate, after stirring, add 40L of OP-10, mix well, that is, compound emulsifier, ready for use;

[0026] 2) Put 400L of mixed solvent (methanol+ethanol, 1:1) into another reactor or agitating tank, add 0.2kg of 10-hydroxycamptothecin with a purity of more than 90%, stir and dissolve completely, add 1.8kg of mixed solvent with a purity of more than 90 % Fipronil above, stir to dissolve, add 30L Tween-80 and stir evenly, add 10L JFC and 1L Azone, stir evenly to obtain the final product.

Embodiment 3

[0028] 1) Put 100L of dimethylformamide into the reactor or stirring tank, add 40L of calcium dodecylbenzene sulfonate, and after stirring, add 30L of OP-10 and 30L of Tween-80 and stir evenly, that is, a compound emulsifier, spare;

[0029] 2) Put 400L of dimethyl sulfoxide into another reactor or stirring tank, add 0.3kg of camptothecin with a purity of 90% and 0.2kg of 10-hydroxycamptothecin with a purity of 90%, heat to 35℃ and Stir constantly, after completely dissolving, add 20L of the above-mentioned composite emulsifier, and after stirring evenly, add 5L JFC and 2L Azone, stir evenly to obtain the final product.

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Abstract

Disclosed is the agricultural pesticide containing camptothecine or camptothecine derivatives and the use thereof, wherein the pesticide comprises camptothecine or its derivatives 0.02-2.0%, emulsifying agent 1.0-20%,penetrating agent 0.5-10%, and balancing organic solvent. The pesticide can be used for controlling agronomic crop downy mildew, leaf streak, pythium blight, head blight, root and stem rot, rhizoctonia rot, damping-off, wilt,bitter rot, powdery mildew, black shank, brown spot, leaf scab, ring rot, black pox, gray mold,phytophthora rot, ulcer disease, black spot, bacterial wilt, angular leaf spot, leaf streak and leaf scar.

Description

Technical field [0001] The invention belongs to the technical field of plant-derived fungicides, and is specifically agricultural fungicides containing camptothecin or camptothecin derivatives and applications thereof. Background technique [0002] Camptothecin (hydroxycamptothecin) is a pyrroloquinoline alkaloid. The general chemical structure of camptothecin and its derivatives is as general formula (I): [0003] [0004] General formula (I) [0005] Among them, R1-10 in the chemical structure represents hydrogen atom, methyl, ethyl, propyl, butyl, hydroxyl, nitro, amino, oxymethyl, methoxyl, fluoroethyl, chloroethyl , One of bromoethyl, nitrogen, silyl, and alkoxy. Camptothecin is mainly derived from Camptotheca acuminata, a unique plant in my country. It was isolated from a camptotheca stalk introduced in my country by Wall et al. in 1966. Camptothecin and its derivatives use topo I as the target to inhibit DNA synthesis and exert anti-cancer effects. It has significant effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01P3/00
Inventor 张立钦马建义马良进王品维刘兴泉毛胜凤
Owner YIFAN AGRI CHEM PLANT ZHEJIANG PROV
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