Equipment for preparing dropping pill with air cooled by cold trap

Abstract

The invention relates to equipment for preparing pills by cold trap and cooling air, which comprises a pill device, a cooling duct hermetically communicated with the pill device and a refrigerating device connected with the cooling duct and circularly conveying a coolant to the outer side of the cooling dust. The pill device is composed of a melting can, a dripper and a heat preserving chamber outside the dripper that are interconnected; the upper port of the cooling duct is hermetically communicated with an opening at the lower end of the heat preserving chamber, while the lower end is corresponding to a pills-collecting vessel. The refrigerating device is provided with a coolant storage tank, a freezer connected with the coolant storage tank and a jacket communicated with the coolant storage tank, circulating the coolant inside and tightly sleeved on the outer side of the cooling duct. The equipment of the invention prepares pills in an air cooling mode, which can avoid the subsequent residual solution process in the traditional condensing way by adopting liquids like whiteruss, silicone oil and so on, simplifying the operational process, having no organic solvent residual and reducing the cost for preparing the pills. The equipment adopts a straight pipeline, thus having no dead angle for cleaning, being convenient for cleaning and being able to avoid the cross contamination in the production process, which is beneficial for the stability of the product.

Description

technical field [0001] The invention relates to a pharmaceutical device. In particular, it relates to a device for preparing dropping pills by using cold trap cooling gas, which has simple preparation process, no organic residue problem, no hidden danger of cross-contamination, and is easy to clean. Background technique [0002] The preparation of traditional drop pills is obtained by dropping the melted material into a liquid lysozyme immiscible with the material, and the refrigerant can be a water-soluble solvent or an oil-soluble solvent. Among them, water-soluble solvents are mostly water, glycerin, etc.; oil-soluble solvents are mostly paraffin oil and silicone oil. Adopt oil-soluble solvent to cool the dripping pill that makes, and the problem that cooling liquid remains is unavoidable. Subsequent oil throwing and oil wiping processes are indispensable, but they cannot solve the problem of organic residues. At the same time, due to the adhesiveness of silicone oil an...

AI Technical Summary

Problems solved by technology

Dropping pills made by cooling with oil-soluble solvents, cooling liquid residue is an unavoidable problem

Subsequent oil throwing and oil wiping processes are indispensable, but they cannot solve the problem of organic residues; at the same time, due to the adhesiveness of silicone oil and other cooling fluids, the equipment cannot be completely cleaned, which becomes a hidden danger of cross-contamination, which is a problem faced by GMP companies today

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