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Two-channel self calibrating multiple parameters rapid whole blood biochemistry analyzing sensor

A sensor, self-calibration technology, applied in the field of biosensors, can solve complex problems

Inactive Publication Date: 2009-12-16
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the current literature and patent reports, the fluid control of the calibration solution and the measured blood is more complicated, requiring control elements such as pumps and valves, such as the i-STAT handheld blood gas / pH+electrolyte analyzer produced by i-STAT

Method used

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  • Two-channel self calibrating multiple parameters rapid whole blood biochemistry analyzing sensor

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Embodiment Construction

[0014] Such as figure 1 As shown, a dual-channel self-calibrating multi-parameter rapid whole blood biochemical analysis sensor includes an upper hydrophilic coating film 2, a lower sensor substrate 1, and is arranged between the upper hydrophilic coating film 2 and the lower sensor substrate 1. The lower sensor substrate 1 is provided with a calibration liquid channel and a test liquid channel. The calibration liquid channel is composed of a calibration liquid injection area 4, a micro flow channel 5, and a calibration liquid waste liquid recovery tank 12. The test liquid channel is composed of a test liquid injection area 8, a micro flow channel 9, and a test liquid waste liquid recovery pool 11.

[0015] There are several pairs of blood chemistry, blood electrolyte and blood gas measuring electrodes arranged symmetrically in the two microfluidic channels 5 and 9, respectively forming a calibration electrode array 7 and a measuring electrode array 6. The two working electrodes o...

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Abstract

The invention discloses a dual-channel self-calibration multi-parameter fast whole blood biochemical analysis sensor, which comprises an upper hydrophilic coating, a lower sensor substrate and a calibration liquid bag, the lower sensor substrate is provided with a calibration liquid channel and a test liquid channel, Each channel is composed of an injection area, a microfluidic channel and a waste liquid recovery pool. Several pairs of blood chemistry, blood electrolyte and blood gas measurement electrodes are symmetrically arranged in the two microfluidic channels, which respectively constitute a calibration electrode array and a measurement electrode array. Each pair The same kind of biochemical reagents involved in the measurement reaction are immobilized on the two working electrodes of the electrodes, and different kinds of enzymes or electrolytes and blood gas sensitive substances are immobilized between each pair of electrodes. The invention solves the problem of on-site calibration in fast whole blood analysis by utilizing the highly consistent and simple dual-channel structure of closely adjacent electrodes produced in the same batch, without additional electromechanical structure, greatly improving the measurement speed and reducing the test cost.

Description

Technical field [0001] The invention relates to a biosensor, in particular to a dual-channel self-calibrating multi-parameter rapid whole blood biochemical analysis sensor. Background technique [0002] Clinical biochemical test is an indispensable method for blood composition analysis. Traditional clinical biochemical tests are carried out on large-scale biochemical analyzers in hospitals. The samples need to be transmitted without contamination and performed by professional operators. They are time-consuming and expensive. They cannot adapt to the trend of home medical care, nor can they meet the needs of surgery, emergency care, field rescue, etc." Time is the need of the occasion of life. Point of Care Testing (POCT) allows doctors to make the most efficient clinical judgments in the shortest possible time, bringing revolutionary advances to medical treatment. At present, the bedside test items mainly focus on the analysis of blood biochemistry, blood electrolytes, blood gas ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/416G01N27/00G01N33/48
Inventor 李光王酉胡萌
Owner ZHEJIANG UNIV
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