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Method for extracting and purifying secoisolariciresinol diglucoside from flax seed

A technology of secoisolaricus and glucoside, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of scale limitation, application space limitation, high cost, etc., achieve easy recycling and improve safety , to overcome the effect of small batch

Inactive Publication Date: 2008-01-30
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the limitation of the separation and purification stage, this method for preparing SDG has high cost and large scale limitation
At the same time, when silica gel is used for adsorption, the solvents used include toxic solvents such as methanol, chloroform and methylene chloride, so the application space is greatly limited

Method used

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  • Method for extracting and purifying secoisolariciresinol diglucoside from flax seed
  • Method for extracting and purifying secoisolariciresinol diglucoside from flax seed
  • Method for extracting and purifying secoisolariciresinol diglucoside from flax seed

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Weigh 50 g of linseed hulls, crush to 30 mesh, add 500 mL of n-hexane, stir at room temperature for 1 h, and then centrifuge (3000 rpm, 20 min). The residue was degreased again with 500 mL of n-hexane. Add 1000mL of 50% ethanol solution to the defatted flaxseed husk, and stir and extract at 25°C for 4h. Then centrifuge (3000rpm, 20min), add 250mL 50% ethanol solution to the residue, stir and extract for 1h, and then centrifuge. Combine the extracts, add 60mL 6M NaOH solution, stir at 30°C for 2h, then add 6M hydrochloric acid to adjust the pH to 4. Then suction filter and wash the residue with an appropriate amount of ethanol, and combine the filtrates. The filtrate was concentrated under reduced pressure to a thick slurry, reconstituted by adding an appropriate amount of absolute ethanol, and then microfiltered (0.45 μm). Then, the sample was loaded and eluted on a Sephadex LH-20 column with a column length of 100 cm and a column diameter of 1.60 cm. After loading,...

Embodiment 2

[0029] Weigh 50 g of linseed, crush it to 100 mesh, add 1000 mL of No. 6 solvent oil, stir at room temperature for 2 h, and then centrifuge (3000 rpm, 20 min). The residue was degreased again with 250 mL No. 6 solvent oil. Add 500mL of 60% ethanol solution to the defatted linseed husk, and extract with stirring at 60°C for 2h. Then centrifuge (3000rpm, 20min), add 250mL 60% ethanol solution to the residue, stir and extract for 1h, and then centrifuge. Combine the extracts, add 75mL 6M NaOH solution, stir at 30°C for 2h, then add 6M hydrochloric acid to adjust the pH to 6. Then suction filter and wash the residue with an appropriate amount of ethanol, and combine the filtrates. The filtrate was concentrated under reduced pressure to a thick slurry, reconstituted by adding an appropriate amount of absolute ethanol, and then microfiltered (0.45 μm). Then, the sample was loaded and eluted on a Sephadex LH-20 column with a column length of 100 cm and a column diameter of 1.60 cm...

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Abstract

The invention relates to the method used to extract purification secoisolarciresinol di-glycoside from flax seed. It belongs to farm produce resource development and functionality health foods technique field. It includes the following steps: using flax seed as raw material; low temperature leaching degreasing by organic solvent; extracting by alcohol solution; adding alkali to hydrolyze; neutralizing and adjusting pH value; reducing pressure and condensing; micro-straining; and purifying. It has superiority in security, economical efficiency, preparation scale, and product purity. Its use is functionality food mixture or health foods.

Description

technical field [0001] A method for extracting and purifying secoisolaricoresinol diglucoside from flaxseeds. The invention relates to a method for extracting and purifying flax lignans, and belongs to the technical field of agricultural product resource development and functional health food. Background technique [0002] Lignans are substances present in plants with estrogenic activity. Flaxseed is rich in flax lignans, the main component of which is secoisolariciresinol diglucoside, English name secoisolariciresinol diglucoside, referred to as SDG, it is a bimolecular polymerization of phenylpropanoid Arylbutane lignans have a mild function similar to human estrogen. It has the activity of inhibiting the growth of human breast cancer cells, reducing breast tumors, reducing the incidence of breast cancer, alleviating women's menopausal symptoms, preventing colon cancer, and inhibiting prostate cancer. It is also effective for lupus nephritis, type I diabetes and type II ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/06C07H15/203
Inventor 许时婴王璋张文斌张晓鸣钟芳
Owner JIANGNAN UNIV
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