Preparation for treating allergic rhinitis and asthma
A technology for allergic rhinitis and asthma, which is applied in the field of preparations for the treatment of allergic rhinitis and asthma. It can solve problems such as difficulty in extraction and separation, failure to meet market demand, difficulty in drug quality control, etc., and achieve stable and reliable products.
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Embodiment 1
[0032] Prepare 10% isofaskolin according to the following process steps:
[0033] 1. Make the dried root of Coleus forskohlii into a coarse powder, and use 95% ethanol to carry out heat reflux extraction in order of 9 times, 7 times, 7 times, and 7 times, each extraction for 1 hour, and combined extraction Liquid, concentrated to 50% volume;
[0034] 2. Add active carbon to decolorize by 0.1% (mass ratio) of the solution amount, remove impurities once with a short silica gel column, and concentrate to dryness to obtain an extract containing 10% isofaskolin.
Embodiment 2
[0036] Prepare 80% isofaskolin according to the following process steps:
[0037] 1. Make the dry product of Coleus forskohlii into a coarse powder, and use 95% ethanol to carry out heat reflux extraction in order of 9 times, 7 times, 7 times, and 7 times, each extraction for 1 hour, and combine the extracts , concentrated to 50% of the amount;
[0038] 2. Add activated carbon to decolorize according to 0.1% (mass ratio) of the solution amount, remove impurities once with a short silica gel column, and concentrate to 5% amount:
[0039] 3. Add 8 times the amount of chloroform or dichloromethane under stirring, and place it overnight at 5-10 ° C. After separating the chloroform or dichloromethane layer, filter it, concentrate it in a vacuum until dry, and obtain 80% isofeskoline the extract;
[0040] 4. Separation on a silica gel column, eluting fractions with the following solvents: petroleum ether (boiling point 60-80°C), petroleum ether-benzene mixture, benzene, benzene-et...
Embodiment 3
[0043] According to the physical and chemical properties of isoferskolin, supercritical (SC-CO 2 ) extraction method to extract isoflurane, that is, the solvent selects CO 2 , CO 2 Entrained ethanol, CO 2 Entrained methanol, etc., the extraction temperature is 45-65°C, the extraction pressure is 30-50Mpa, the analysis pressure is 8-14Mpa, and the analysis temperature is 42-67°C. The advantage is that the method belongs to clean production, and there are few residual solvents in the extract. Strict control of the conditions and the amount of entrained solvent can yield isofeskoline.
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