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31 results about "Juvenile osteoporosis" patented technology
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Juvenile osteoporosis is osteoporosis in children and adolescents. Osteoporosis is rare in children and adolescents. When it occurs, it is usually secondary to some other condition, e.g. osteogenesis imperfecta, rickets, eating disorders or arthritis. In some cases, there is no known cause and it is called idiopathic juvenile osteoporosis. Idiopathic juvenile osteoporosis usually goes away spontaneously.
Kit for juvenile osteoporosis detection
InactiveCN106755522AEffective early diagnosisReduce deformity rateMicrobiological testing/measurementDNA/RNA fragmentationDysostosisNormal people
The invention discloses a kit for juvenile osteoporosis detection. Through gene comparison, the fact that compared with a DKK1 gene in the normal people group, a juvenile form osteoporosis patient has the obvious mutant site is discovered, and the obvious mutant site is the 721 site. Through detecting the mutant site, particularly through the pair of provided specific primer pair, whether the people has the juvenile form osteoporosis symptom or not can be specifically identified. Compared with the prior art, the detection method has the advantages that the detection is convenient; accuracy and high speed are realized; the kit is suitable for being popularized and used.
Owner:SUZHOU UNIV
Kit for detecting juvenile osteoporosis
ActiveCN106868125AEffective early diagnosisReduce deformity rateMicrobiological testing/measurementDNA/RNA fragmentationJuvenile osteoporosisCrowds
The invention discloses a kit for detecting juvenile osteoporosis. According to the kit, an obvious mutant site which is a site 1020 is discovered to exist in a DKK1 gene in a patient suffering from the juvenile osteoporosis and a normal crowd through genetic comparison. Through detecting the mutant site, particularly provided one pair of specific primer pairs, a human body which suffers from the juvenile osteoporosis can be specifically identified. Compared with the method in the prior art, a detection method has the advantages of being quick for detection, accurate and quick, and is suitable to popularize and use.
Owner:SUZHOU UNIV
H3k27 demethylase inhibitors in pediatric and juvenile osteoporosis
ActiveUS20200222419A1Increase of methylationSkeletal disorderHeterocyclic compound active ingredientsSpinal columnGlucocorticoid
The present invention provides methods for manipulating epigenetic factors to treat pediatric or juvenile osteoporosis. Specifically, the present invention provides methods for the application of H3K27 demethylase inhibitors in pediatric or juvenile subjects with osteoporosis. Thus, the present invention provides methods of administration of the H3K27 demethylase inhibitor, GSK-J4, to pediatric or juvenile subjects to effectively inhibit primary and secondary pediatric osteoporosis, especially for long-term glucocorticoid treated patients (juvenile rheumatoid disorders, Crohn's disease, nephrotic syndrome, and Duchenne muscular dystrophy) and patients who have compromised mobility (cerebral palsy, Rett syndrome, Duchenne muscular dystrophy, spina bifida, and spinal muscular atrophy).
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Kit for detecting juvenile osteoporosis based on rs6866306
PendingCN109762888AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs6866306. The kit includes a specific primer pair for detecting an SNP locus of rs6866306, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs6866306 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
A kit for juvenile osteoporosis detection
InactiveCN106755522BEffective early diagnosisReduce deformity rateMicrobiological testing/measurementDNA/RNA fragmentationPhysiologyJuvenile osteoporosis
The invention discloses a kit for juvenile osteoporosis detection. Through gene comparison, the fact that compared with a DKK1 gene in the normal people group, a juvenile form osteoporosis patient has the obvious mutant site is discovered, and the obvious mutant site is the 721 site. Through detecting the mutant site, particularly through the pair of provided specific primer pair, whether the people has the juvenile form osteoporosis symptom or not can be specifically identified. Compared with the prior art, the detection method has the advantages that the detection is convenient; accuracy and high speed are realized; the kit is suitable for being popularized and used.
Owner:SUZHOU UNIV
Kit for detecting juvenile osteoporosis based on rs72906356
PendingCN109762892AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs72906356. The kit includes a specific primer pair for detecting an SNP locus of rs72906356, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs72906356 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs6866306
InactiveCN109609626AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs6866306. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs6866306, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs6866306 closely related to the genetic susceptibility to the juvenile osteoporosis.
Owner:刘露
Kits for the detection of juvenile osteoporosis
ActiveCN106868125BEffective early diagnosisReduce deformity rateMicrobiological testing/measurementDNA/RNA fragmentationHuman bodyPhysiology
The invention discloses a kit for detecting juvenile osteoporosis. According to the kit, an obvious mutant site which is a site 1020 is discovered to exist in a DKK1 gene in a patient suffering from the juvenile osteoporosis and a normal crowd through genetic comparison. Through detecting the mutant site, particularly provided one pair of specific primer pairs, a human body which suffers from the juvenile osteoporosis can be specifically identified. Compared with the method in the prior art, a detection method has the advantages of being quick for detection, accurate and quick, and is suitable to popularize and use.
Owner:SUZHOU UNIV
Kit for detecting juvenile osteoporosis based on rs146551666
PendingCN109762886AImprove accuracyStrong specificityMicrobiological testing/measurementDysostosisFluorescence
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs146551666. The kit includes a specific primer pair for detecting an SNP locus of rs146551666, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs146551666 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for specifically detecting juvenile osteoporosis by detecting rs12408576
PendingCN109837337AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs12408576. The kit comprises a specific primer pair and a specific fluorescent probe pair used for detecting the SNP site of the rs12408576, and a conventional assembly used for fluorescent quantitative PCR detection. The kit of the invention evaluates the genetic susceptibility of the individual osteoporosis by simultaneously detecting the genotype of the single nucleotide polymorphism site on the rs12408576 which is closely related to the genetic susceptibility of the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs310749
InactiveCN109666733AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for detecting juvenile osteoporosis in a specificity mode by detecting rs310749. The kit comprises a specific primer pair, a specific fluorescence probe pair, a conventional assembly used for fluorescent quantitative PCR detection and the like, wherein the specific primer pair and the specific fluorescence probe pair are used for detecting the SNP site of number rs310749. The kit evaluates the genetic predisposition of individual osteoporosis by detecting a single nucleotide polymorphism site gene type on the rs310749 closely related to the genetic predispositionof the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs72906356
InactiveCN109666732AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for detecting juvenile osteoporosis in a specificity mode by detecting rs72906356. The kit comprises a specific primer pair, a specific fluorescence probe pair, a conventional assembly used for fluorescent quantitative PCR detection and the like, wherein the specific primer pair and the specific fluorescence probe pair are used for detecting the SNP site of number rs72906356. The kit evaluates the genetic predisposition of individual osteoporosis by detecting a single nucleotide polymorphism site gene type on the rs72906356 closely related to the genetic predisposition of the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs11841272
InactiveCN109666731AImprove accuracyStrong specificityMicrobiological testing/measurementJuvenile osteoporosisNucleotide
The invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs11841272. The kit comprises a specific primer pair for detecting rs11841272 SNP loci, a specific fluorescent probe pair, a conventional assembly for fluorogenic quantitative PCR detection and the like. According to the kit, the individual osteoporosis genetic predisposition is evaluated by detecting the genotype of single nucleotide polymorphic sites on rs11841272 closely related to juvenile osteoporosis genetic predisposition at the same time.
Owner:刘露
Kit for specifically detecting juvenile osteoporosis by detecting rs2012627
PendingCN109797213AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs2012627. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting an SNP site with No. rs2012627, conventional components for fluorescent quantitative PCR detection, and the like. The kit evaluates individual osteoporosis genetic susceptibility by simultaneously detecting single nucleotide polymorphism site genotype on rs2012627 which is closely related to juvenile osteoporosis genetic susceptibility.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs7156107
InactiveCN109609622AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs7156107. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs7156107, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs7156107 closely related to the genetic susceptibility to the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs13055979
InactiveCN109609621AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs13055979. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs13055979, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs13055979 closely related to the genetic susceptibility to the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs2531992
PendingCN109762890AImprove accuracyStrong specificityMicrobiological testing/measurementDysostosisFluorescence
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs2531992. The kit includes a specific primer pair for detecting an SNP locus of rs2531992, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs2531992 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs7532173
InactiveCN109609623AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs7532173. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs7532173, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs7532173 closely related to the genetic susceptibility to the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs7532173
PendingCN109762891AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs7532173. The kit includes a specific primer pair for detecting an SNP locus of rs7532173, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs7532173 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs11841272
PendingCN109666736AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for detecting juvenile osteoporosis in a specificity mode by detecting rs11841272. The kit comprises a specific primer pair, a specific fluorescence probe pair, a conventional assembly used for fluorescent quantitative PCR detection and the like, wherein the specific primer pair and the specific fluorescence probe pair are used for detecting the SNP site of number rs11841272. The kit evaluates the genetic predisposition of individual osteoporosis by detecting a single nucleotide polymorphism site gene type on the rs11841272 closely related to the genetic predisposition of the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs1992011
InactiveCN109652534AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for detecting juvenile osteoporosis based on detection of specificity of rs1992011. The kit comprises a specificity primer, a specificity fluorescent probe pair and a common assembly, wherein the specificity primer is used for detecting an rs1992011 SNP site, and the common assembly is used for fluorescent quantitative PCR detection. The kit evaluates the geneticpredisposition of individual osteoporosis by detecting the type of a gene on the single nucleotide polymorphism site on rs1992011 closely related to the genetic disposition of juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs310749
PendingCN109762894AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationJuvenile osteoporosisOsteopoikilosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs310749. The kit includes a specific primer pair for detecting an SNP locus of rs310749, a specific fluorescentprobe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detectinga single nucleotide polymorphism locus genotype on rs310749 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs6470763
PendingCN109762889AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs6470763. The kit includes a specific primer pair for detecting an SNP locus of rs6470763, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs6470763 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs73403830
PendingCN109762887AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs73403830. The kit includes a specific primer pair for detecting an SNP locus of rs73403830, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs73403830 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs6470763
InactiveCN109609625AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs6470763. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting a SNP site of the rs6470763, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility of individual osteoporosis by simultaneously detecting a single nucleotide polymorphism locus genotype on the rs6470763 which is closely related to the genetic susceptibility to the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs8071778
PendingCN109666737AImprove accuracyStrong specificityMicrobiological testing/measurementDysostosisJuvenile osteoporosis
The invention discloses a kit for detecting juvenile osteoporosis in a specificity mode by detecting rs8071778. The kit comprises a specific primer pair, a specific fluorescence probe pair, a conventional assembly used for fluorescent quantitative PCR detection and the like, wherein the specific primer pair and the specific fluorescence probe pair are used for detecting the SNP site of number rs8071778. The kit evaluates the genetic predisposition of individual osteoporosis by detecting a single nucleotide polymorphism site gene type on the rs8071778 closely related to the genetic predisposition of the juvenile osteoporosis.
Owner:刘露
Kit for specifically detecting juvenile osteoporosis by detecting rs7156107
PendingCN109797214AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs7156107. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting an SNP site with No. rs7156107, conventional components for fluorescent quantitative PCR detection, and the like. The kit evaluates individual osteoporosis genetic susceptibility by simultaneously detecting single nucleotide polymorphism site genotype on rs7156107 which is closely related to juvenile osteoporosis genetic susceptibility.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs13469
PendingCN109825570AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs13469. The kit includes a specific primer pair for detecting the SNP locus of rs13469, a specific fluorescent probe pair and a conventional assembly for fluorescent quantitative PCR detection. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a singlenucleotide polymorphism locus genotype on rs13469 closely related to the genetic susceptibility to the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs13055979
PendingCN109666738AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationDysostosisJuvenile osteoporosis
The invention discloses a kit for detecting juvenile osteoporosis in a specificity mode by detecting rs13055979. The kit comprises a specific primer pair, a specific fluorescence probe pair, a conventional assembly used for fluorescent quantitative PCR detection and the like, wherein the specific primer pair and the specific fluorescence probe pair are used for detecting the SNP site of number rs13055979. The kit evaluates the genetic predisposition of individual osteoporosis by detecting a single nucleotide polymorphism site gene type on the rs13055979 closely related to the genetic predisposition of the juvenile osteoporosis.
Owner:刘露
Kit for detecting juvenile osteoporosis based on rs35079125
PendingCN109762885AImprove accuracyStrong specificityMicrobiological testing/measurementDNA/RNA fragmentationFluorescenceJuvenile osteoporosis
The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs35079125. The kit includes a specific primer pair for detecting an SNP locus of rs35079125, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs35079125 closely related to the genetic susceptibility to juvenile osteoporosis.
Owner:刘露
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