31 results about "Juvenile osteoporosis" patented technology

The present invention provides methods for manipulating epigenetic factors to treat pediatric or juvenile osteoporosis. Specifically, the present invention provides methods for the application of H3K27 demethylase inhibitors in pediatric or juvenile subjects with osteoporosis. Thus, the present invention provides methods of administration of the H3K27 demethylase inhibitor, GSK-J4, to pediatric or juvenile subjects to effectively inhibit primary and secondary pediatric osteoporosis, especially for long-term glucocorticoid treated patients (juvenile rheumatoid disorders, Crohn's disease, nephrotic syndrome, and Duchenne muscular dystrophy) and patients who have compromised mobility (cerebral palsy, Rett syndrome, Duchenne muscular dystrophy, spina bifida, and spinal muscular atrophy).

The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs6866306. The kit includes a specific primer pair for detecting an SNP locus of rs6866306, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs6866306 closely related to the genetic susceptibility to juvenile osteoporosis.

The invention discloses a kit for juvenile osteoporosis detection. Through gene comparison, the fact that compared with a DKK1 gene in the normal people group, a juvenile form osteoporosis patient has the obvious mutant site is discovered, and the obvious mutant site is the 721 site. Through detecting the mutant site, particularly through the pair of provided specific primer pair, whether the people has the juvenile form osteoporosis symptom or not can be specifically identified. Compared with the prior art, the detection method has the advantages that the detection is convenient; accuracy and high speed are realized; the kit is suitable for being popularized and used.

The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs72906356. The kit includes a specific primer pair for detecting an SNP locus of rs72906356, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs72906356 closely related to the genetic susceptibility to juvenile osteoporosis.

The invention discloses a kit for detecting juvenile osteoporosis. According to the kit, an obvious mutant site which is a site 1020 is discovered to exist in a DKK1 gene in a patient suffering from the juvenile osteoporosis and a normal crowd through genetic comparison. Through detecting the mutant site, particularly provided one pair of specific primer pairs, a human body which suffers from the juvenile osteoporosis can be specifically identified. Compared with the method in the prior art, a detection method has the advantages of being quick for detection, accurate and quick, and is suitable to popularize and use.

The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs7156107. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs7156107, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs7156107 closely related to the genetic susceptibility to the juvenile osteoporosis.

The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs13055979. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs13055979, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs13055979 closely related to the genetic susceptibility to the juvenile osteoporosis.

The present invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs7532173. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting SNP sites of the rs7532173, a conventional component for fluorescence quantitative PCR detection, etc. The kit assesses genetic susceptibility to individual osteoporosis by simultaneously detecting single nucleotide polymorphism locus genotypes on the rs7532173 closely related to the genetic susceptibility to the juvenile osteoporosis.

The invention discloses a kit for specifically detecting juvenile osteoporosis by detecting rs13469. The kit includes a specific primer pair for detecting the SNP locus of rs13469, a specific fluorescent probe pair and a conventional assembly for fluorescent quantitative PCR detection. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a singlenucleotide polymorphism locus genotype on rs13469 closely related to the genetic susceptibility to the juvenile osteoporosis.

The invention discloses a kit for specifically detecting juvenile osteoporosis based on rs35079125. The kit includes a specific primer pair for detecting an SNP locus of rs35079125, a specific fluorescent probe pair, a conventional component for fluorescent quantitative PCR detection, and the like. The kit assesses the genetic susceptibility of osteoporosis in an individual by simultaneously detecting a single nucleotide polymorphism locus genotype on rs35079125 closely related to the genetic susceptibility to juvenile osteoporosis.