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Marker combinations for diagnosing infections and methods of use thereof

a technology of diagnostic tests and markers, applied in the field of identification of biological signatures and determinants, can solve problems such as prolonged hospitalization, ineffective abx, and reducing the quality of healthcar

Inactive Publication Date: 2017-09-21
MEMED DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect of this patent is that it limits the number of determindents (measurable factors) in a system or process to only one or at most two per measurement. This helps improve accuracy and efficiency when measuring various parameters within a given space.

Problems solved by technology

This patent discusses identifying biological signs and determining factors associated with bacterial and viral infections through various means like DNA sequencing and analysis. However, current technologies used for this purpose face limitations including poor diagnostic accuracy, requiring long time frames, failing to distinguish between different types of bacteria, and requiring access to the infection site. These issues lead to incorrect prescribing of antibiotics by medical professionals, contributing to the growing problem of antibiotic resistance. Therefore, there is a technical need for a fast and accurate way to identify the cause of infection without compromising patient care or promoting excessive use of antibiotics.

Method used

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  • Marker combinations for diagnosing infections and methods of use thereof
  • Marker combinations for diagnosing infections and methods of use thereof
  • Marker combinations for diagnosing infections and methods of use thereof

Examples

Experimental program
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Effect test

example 1

Identifying Host-Proteome Signatures for Distinguishing Between Acute Bacterial and Viral Infections

[0426]Patients were recruited as part of a multi-center, observational, prospective clinical study with the aim to develop and test a host proteins-signature for the purpose of rapid and accurate diagnosis of patients with viral and bacterial diseases.

[0427]Methods

[0428]Patient Recruitment:

[0429]A total of 122 patients were recruited of whom 111 had a suspected infectious disease and 11 had a non-infectious disease (control group). Informed consent was obtained from each participant or legal guardian, as applicable. Inclusion criteria for the infectious disease cohort included: clinical suspicion of an acute infectious disease, peak fever >37.5° C. since symptoms onset, and duration of symptoms ≦12 days. Inclusion criteria for the control group included: clinical impression of a non-infectious disease (e.g. trauma, stroke and myocardial infarction), or healthy subjects. Exclusion crit...

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PUM

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Abstract

A method of determining an infection type in a subject is disclosed. The method comprises measuring the concentration of a first determinant selected from the group consisting of the determinants which are set forth in Table 1 and a second determinant selected from the group of the determinants which are set forth in Table 2 in a subject derived sample, wherein the concentration is indicative of the infection type.

Description

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Claims

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Application Information

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Owner MEMED DIAGNOSTICS
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