Marker combinations for diagnosing infections and methods of use thereof
a technology of diagnostic tests and markers, applied in the field of identification of biological signatures and determinants, can solve problems such as prolonged hospitalization, ineffective abx, and reducing the quality of healthcar
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Identifying Host-Proteome Signatures for Distinguishing Between Acute Bacterial and Viral Infections
[0426]Patients were recruited as part of a multi-center, observational, prospective clinical study with the aim to develop and test a host proteins-signature for the purpose of rapid and accurate diagnosis of patients with viral and bacterial diseases.
[0427]Methods
[0428]Patient Recruitment:
[0429]A total of 122 patients were recruited of whom 111 had a suspected infectious disease and 11 had a non-infectious disease (control group). Informed consent was obtained from each participant or legal guardian, as applicable. Inclusion criteria for the infectious disease cohort included: clinical suspicion of an acute infectious disease, peak fever >37.5° C. since symptoms onset, and duration of symptoms ≦12 days. Inclusion criteria for the control group included: clinical impression of a non-infectious disease (e.g. trauma, stroke and myocardial infarction), or healthy subjects. Exclusion crit...
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