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Agents inhibiting granulin for treatment of cancer

Inactive Publication Date: 2017-04-06
LANDBERG GORAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a method for treating cancer stem cells, which are a type of cancer cell that can spread and come back after treatment. The method involves using agents that inhibit a protein called progranulin, which is involved in the growth of cancer stem cells. By blocking this protein, the agents can reduce the activity of cancer stem cells and prevent the formation of new tumors. This approach may be useful in treating a range of cancer types and may help reduce the need for aggressive treatments that can have side effects. The patent also notes that granulin, a different protein, is associated with inflammation, which can promote cancer stem cell activity. Therefore, the methods described in this patent may also be beneficial in treating cancer associated with inflammation.

Problems solved by technology

If cancer cells do not express sortilin, then there is likely to be little therapeutic benefit from treatment with agents that inhibit granulin signalling, or that inhibit sortilin activity.

Method used

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  • Agents inhibiting granulin for treatment of cancer
  • Agents inhibiting granulin for treatment of cancer
  • Agents inhibiting granulin for treatment of cancer

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Embodiment Construction

[0024]To improve the understanding of the invention, useful definitions will now be provided in respect of certain terms used in the present disclosure.

“Granulin Signalling”

[0025]For the purposes of the present disclosure references to “granulin signalling” should be construed as encompassing signalling by granulin and its precursors (such as progranulin), and products of the cleavage of progranulin or granulin (including paragranulin and the granulin 1 or 5 domains), such as by metalloproteases.

“Agents that Inhibit Granulin Signalling”

[0026]In their broadest embodiments, the methods or uses of the invention may be put into practice using any agent that inhibits granulin signalling. It will be appreciated that suitable agents may achieve this required inhibition in granulin signalling by a number of different approaches. Suitably, an agent that inhibits granulin signalling may be one that reduces granulin expression, thus decreasing the amount of granulin that is available to take p...

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Abstract

The disclosure provides agents that inhibit granulin signalling for use as medicaments to reduce cancer stem cell activity in the treatment of cancer. The disclosure also provides agents that inhibit soluble granulin signalling for use in the treatment of cancer. The treatments of the disclosure may be of particular utility in breast cancer; prostate cancer; and melanoma, and are also of use in treatment of cancers associated with hypoxic tumours. Suitable agents may include those that inhibit granulin expression, inhibit granulin cleavage, or bind to and inhibit soluble granulin. Such agents may be used in combination with inhibitors of angiogenesis.

Description

[0001]The present invention relates to methods of reducing cancer stem cell activity, the medical use of agents to reduce cancer stem cell activity in the treatment of cancer, and medical uses of agents in the treatment of cancer.[0002]The invention also relates to methods of reducing cancer stem cell activity in a subject, and to methods of treating cancer in a subject.[0003]The invention further relates to methods by which agents may be screened for their suitability for use in methods of reducing cancer stem cell activity, medical use to reduce cancer stem cell activity in the treatment of cancer, and medical use in the treatment of cancer.[0004]The invention also relates to cell culture media and supplements.BACKGROUND[0005]Treatment of solid tumours such as breast cancer often target the bulk of the tumour population leaving behind treatment resistant cells with stem cell like properties. These stem cell-like cells have been implicated in the generation of recurrent disease (Ri...

Claims

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Application Information

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IPC IPC(8): C07K16/28G01N33/50A61K31/7088A61K45/06A61K39/395C12N15/113
CPCC07K16/286A61K39/39558C12N15/113A61K31/7088A61K45/06G01N2333/705C07K2317/76C12N2310/11C12N2310/14A61K2039/505G01N33/5011C07K14/475G01N33/5041A61K38/06A61K38/07A61K38/57A61K31/16A61K31/17A61K31/4192A61K31/4196A61P35/00A61K2300/00
Inventor LANDBERG, GORAN
Owner LANDBERG GORAN
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