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Coatings for Medical Devices Comprising a Therapeutic Agent and a Metallic Material

a technology of metallic materials and medical devices, applied in the field of medical devices comprising a therapeutic agent and a metallic material, can solve the problems of inflammation of the body lumen, use of polymers in medical device coatings, etc., and achieve the effect of suitable release rate of therapeutic agents, and reducing the amount of polymer conta

Inactive Publication Date: 2012-12-20
BOSTON SCI SCIMED INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a medical device, such as an implantable intravascular stent, with a coating that reduces or eliminates polymer contact with the body tissue, while still providing a suitable release rate of the therapeutic agent. The coating comprises a first coating composition containing the therapeutic agent and a second coating composition containing metallic material. The second coating composition is substantially free of polymer. The coating can be applied to the stent sidewall structure and can include pores. The invention also includes a stent sidewall structure with a plurality of openings and a coating that conforms to the stent sidewall structure to preserve the openings.

Problems solved by technology

However, the use of polymers in medical device coatings can also have some disadvantages.
For example, depending on the type of polymer used to coat the medical device, some polymers can cause inflammation of the body lumen, offsetting the effects of the therapeutic agent.
Additionally, some polymers may also cause thrombosis.

Method used

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  • Coatings for Medical Devices Comprising a Therapeutic Agent and a Metallic Material
  • Coatings for Medical Devices Comprising a Therapeutic Agent and a Metallic Material
  • Coatings for Medical Devices Comprising a Therapeutic Agent and a Metallic Material

Examples

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Embodiment Construction

[0033]The present invention is directed to a medical device comprising a coating comprising a first coating composition containing a therapeutic agent and optionally a polymer. The medical device also includes a second coating composition containing a metallic material and is substantially free of any polymer.

[0034]In certain embodiments, the coating comprises a first coating composition comprising a therapeutic agent disposed on the surface of the medical device and a second coating composition comprising a metallic material disposed on the first coating composition. The second coating composition is substantially free of any polymer. Also, after the second coating composition is disposed on the first coating composition, wherein the second coating composition comprises a plurality of pores that extend from the outer surface of the first composition to the outer surface of the second coating composition.

[0035]FIG. 1 shows a cross-sectional view an embodiment of a coating disposed o...

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Abstract

The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stent, having a coating comprising a first coating composition comprising a therapeutic agent and, optionally, a polymer; and a second coating composition comprising a metallic material.

Description

FIELD OF THE INVENTION[0001]The invention relates generally to implantable medical devices for delivering a therapeutic agent to the body tissue of a patient, and methods for making such medical devices. In particular, the invention pertains to implantable medical devices, such as intravascular stents, having a coating comprising a first coating composition comprising a therapeutic agent and a second coating composition comprising a metallic material.BACKGROUND OF THE INVENTION[0002]Medical devices have been used to deliver therapeutic agents locally to the body tissue of a patient. For example, intravascular stents comprising a therapeutic agent have been used to locally deliver therapeutic agents to a blood vessel. Often such therapeutic agents have been used to prevent restenosis. Examples of stents comprising a therapeutic agent include stents that comprise a coating containing a therapeutic agent for delivery to a blood vessel. Studies have shown that stents having a coating wi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/82
CPCA61F2/82A61F2002/30322A61F2250/0026A61F2250/0067A61L31/082A61L31/10A61L31/16A61L2300/416A61L2300/608A61L2420/08
Inventor ZHOU, PU
Owner BOSTON SCI SCIMED INC
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