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Bone cement and a method for producing same

Inactive Publication Date: 2012-11-15
AAP BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0057]The use of a pre-polymerized, partially cross-linked polymer, for example in the form of a pearl polymer, after mixing with the monomer, leads to the partial dissolution of the polymer particles and the formation o

Problems solved by technology

Of course, the hardened material* is very brittle, so that a sufficient permanent stability cannot be achieved for many cases of application.
Of course, in the case of calcium phosphate-based bone cements, there is a softening of the material even after a short time, so that in many cases, defect sites cannot be stabilized sufficiently rapidly, particularly in elderly patients.
Bone cements based on calcium sulfate or calcium phosphate-are generally not suitable for the anchoring of dynamic load-bearing implants.
Acrylic-based bone cements generally cannot be degraded by the body.
These types of additives for the most part, of course, are only accessible at the surface of the cement, predominantly surrounded by acrylic and for the most part are not resorbable.
Finall

Method used

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  • Bone cement and a method for producing same
  • Bone cement and a method for producing same
  • Bone cement and a method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Example

EXAMPLE 1

[0066]As a first step, an acrylate-based bone cement composed of a monomer and a polymeric bone cement powder are mixed. A bone cement paste is formed in this way, as it can be used according to the prior art.

[0067]After mixing this paste, another paste that is composed of a suspension of finely dispersed, distributed particles of hydroxyapatite, calcium carbonate, calcium sulfate and / or calcium phosphate are mixed and combined with the bone cement in a suitable mixing device.

[0068]The paste that forms from the two pastes can now be used.

[0069]Instead of first producing the paste from acrylate-based bone cement in a separate step, a concentrated suspension containing hydroxyapatite, calcium carbonate, calcium sulfate and / or calcium phosphate can also be mixed directly with the polymer particles of the acrylate-based bone cement and the monomer.

Example

EXAMPLE 2

[0070]In a first step, a paste composed of an aqueous phase and finely dispersed, distributed particles of hydroxyapatite, calcium carbonate, calcium sulfate and / or calcium phosphate and dibenzoyl peroxide is mixed with a second paste. Optionally, a pharmacologically effective substance [is added]*. The second paste contains methyl(meth) acrylate and / or butyl acrylate as the monomer, dimethyl-p-toluidine as an accelerator and optionally, an x-ray contrast agent. Further, the second paste contains a partially cross-linked PMMA pearl polymer. The two pastes are mixed by means of a suitable mixer with or without a statistical mixing element and can then be introduced into defect sites by means of a syringe or by hand. *Text given in brackets does not appear in the original German text, but is added for clarity.—Translator's note.

[0071]Due to the methyl methacrylate, the PMMA contained in the pearl polymer partially dissolves out from the beads or the beads swell and the otherw...

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Abstract

The invention relates to a bone cement composed of a hydrophilic component and a hydrophobic component, wherein biodegradable material is deposited in pores of the bone cement via the hydrophilic component.

Description

[0001]The invention relates to a bone cement and a method for producing same.BACKGROUND OF THE INVENTION[0002]Different types of bone cement are known from practice. In order to provide a biodegradable bone cement, i.e., a bone cement that is replaced over time after it is applied by new growth of bone tissue, bone cements based on calcium phosphate or calcium sulfate, for example, are known. After they are applied in each case, a sufficient initial stability can be achieved with these bone cements. Of course, the hardened material* is very brittle, so that a sufficient permanent stability cannot be achieved for many cases of application. Calcium phosphates are also known. Of course, in the case of calcium phosphate-based bone cements, there is a softening of the material even after a short time, so that in many cases, defect sites cannot be stabilized sufficiently rapidly, particularly in elderly patients. *presumably based on calcium sulfate, but this is not stated in the German t...

Claims

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Application Information

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IPC IPC(8): C04B24/26A61P19/00A61K47/32A61K6/891
CPCA61L24/0036A61L24/0042A61L24/0084A61K6/087A61L2430/02A61L27/56A61L27/58A61L2300/406A61L27/46A61K6/891A61P19/00
Inventor SATTIG, CHRISTOPHDINGELDEIN, ELVIRA
Owner AAP BIOMATERIALS
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