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Preventive or Therapeutic Drug for Alzheimer-Type Dementia

a technology for alzheimer-type dementia and pre-treatment drugs, which is applied in the field of new drugs, can solve the problems of not revealing or indicating excellent effects on alzheimer-type dementia, products may not be sufficient in view of the fundamental treatment of the disease, etc., and achieves excellent therapeutic effects, high therapeutic effects, and high therapeutic effects. high

Inactive Publication Date: 2009-11-19
MOCHIDA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]In view of the situation as described above, an object of the present invention is to provide a highly safe preventive or therapeutic drug for Alzheimer-type dementia which can replace the conventional therapies currently used for Alzheimer-type dementia or which can be used together with the conventional therapy to realize high therapeutic effects.
[0009]The inventors of the present invention carried out an intensive study on the preventive or therapeutic drug for Alzheimer-type dementia, and found that use of a combination of an ω-3 polyunsaturated fatty acid and a thyroid hormone exhibits excellent therapeutic effects for Alzheimer-type dementia as well as high safety. The present invention has been completed on the basis of such finding.
[0010]The preventive or therapeutic drug for Alzheimer-type dementia wherein an ω-3 polyunsaturated fatty acid is used in combination with a thyroid hormone has significant therapeutic effects for the Alzheimer-type dementia while it exhibits no adverse events, and accordingly, it should provide a highly effective preventive or therapeutic drug for Alzheimer-type dementia with high safety.

Problems solved by technology

This product, however, is indicated for “inhibition of the advance of dementia symptoms of slight or moderate Alzheimer-type dementia”, and this product may not be sufficient in view of fundamental treatment of the disease.
This document, however, does not disclose or indicate excellent effects on the Alzheimer-type dementia achieved by the combination of the ω-3 polyunsaturated fatty acid and thyroid hormone.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

examples

[0028]Next, the present invention is described in further detail by referring to the Examples, which by no means limit the scope of the present invention.

example

Subject and Method

[0029]14 patients (6 males and 8 females in their fifties to eighties) diagnosed with Alzheimer-type dementia but having no history of cerebral infarction and not suffering from primary diseases of dementia such as hypothyroidism were administered with ethyl icosapentate (trade name Epadel; manufactured by Mochida Pharmaceutical Co., Ltd.; abbreviated as “EPA-E” in the Table) at a daily dose of 300 to 600 mg for 2 months, and then, also with levothyroxine sodium (trade name thyradin S; manufactured by ASKA Pharmaceutical Co., Ltd.; abbreviated as “T4” in the Table) at a daily dose of 50 to 100 μg for 4 months in addition to the ethyl icosapentate. Each patient was evaluated for the improvement of the dementia by Hasegawa Dementia Scale at the start of the test, 2 months after the start of the test months from the start of administering ethyl icosapentate), and 6 months after the start of the test (4 months after the start of the combined administration of the ethyl...

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Abstract

It is intended to provide a highly safe preventive or therapeutic drug for Alzheimer-type dementia which can replace the conventional therapies currently used for Alzheimer-type dementia or which can be used together with the conventional therapy to realize high therapeutic effects, characterized in that a ω-3 polyunsaturated fatty acid and thyroid hormone are used in combination.

Description

TECHNICAL FIELD[0001]This invention relates to a novel preventive or therapeutic drug for Alzheimer-type dementia, and more specifically, to a preventive or therapeutic drug for Alzheimer-type dementia wherein an ω-3 polyunsaturated fatty acid is used in combination with a thyroid hormone.BACKGROUND ART[0002]With the progress of aging of the society, number of patients suffering from dementia is ever more increasing. Dementia is the condition in which acquired intelligence has persistently declined by organic disorder of brain. Dementia has been classified into several types based on the pathogenesis and histopathology, and the most typical types are Alzheimer-type dementia and cerebrovascular dementia. Conceivably, these two types of dementia and the mixed type of these two constitute 80 to 90% of the entire dementia case.[0003]Alzheimer-type dementia is associated with atrophy of brain, and up to this moment, no drug has been found that can fundamentally treat this disease. The on...

Claims

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Application Information

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IPC IPC(8): A61K31/20A61P25/28
CPCA61K31/202A61K31/232A61K2300/00A61P25/28A61P43/00
Inventor HASHIZUME, KIYOSHI
Owner MOCHIDA PHARM CO LTD
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