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Monofilament, Surgical Mesh Having Improved Flexibility and Biocompatibility, and Process for Preparing the Same

a mesh and biocompatibility technology, applied in the field ofmono, can solve the problems of excessive stiffness of the mesh, pain to the patient, and potential fistulas of the intestine of polypropylene mesh, and achieve the effect of improving flexibility and biocompatibility

Inactive Publication Date: 2007-09-20
SAMYANG BIOPHARMLS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a monofilament made of degradable and non-degradable polymers that have a segmented pie structure. This monofilament can be used to make a hernia surgical mesh that is more flexible and biocompatible. The invention also provides a method for preparing the hernia mesh."

Problems solved by technology

However, it has been reported that the polypropylene mesh may have the potential to generate fistulas in the intestine (Seelig M H, “A rare complication after incisional hernia repair”.
Therefore, the mesh has excessive stiffness even after the wound has healed, causing pain to the patient due to misfeelings.
However, since the mesh consists of only non-degradable materials, there are also some problems in that the initial strength and stiffness of the mesh are continuously maintained in the body, and an excessive amount of polypropylene remains in the body.
However, since the meshes prepared by the above methods consist of several threads of degradable and non-degradable materials in the combined form, there is a possibility of bacterial infection within the spaces between the threads, which is an inherent defect of multifilaments.
Further, since the methods employ the multifilament form wherein several strands of fiber are combined, the amount of materials required for exhibiting the necessary stiffness is larger than the case of using the monofilament.
As known from the above prior art, although the use of a hernia mesh has been regarded as a basic means in performing hernia repairs, there are unsatisfactory results obtained from the studies to develop a hernia mesh for improving the convenience in performing the operation, reducing the misfeelings, and having improved biocompatibility.

Method used

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  • Monofilament, Surgical Mesh Having Improved Flexibility and Biocompatibility, and Process for Preparing the Same
  • Monofilament, Surgical Mesh Having Improved Flexibility and Biocompatibility, and Process for Preparing the Same
  • Monofilament, Surgical Mesh Having Improved Flexibility and Biocompatibility, and Process for Preparing the Same

Examples

Experimental program
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Effect test

example 1

[0060] The monofilament in the segmented pie form was prepared through conjugated spinning of 55 vol % of a glycolide (75) / caprolactone (25) copolymer as a degradable polymer and 45 vol % of polypropylene as a non-degradable polymer under the conditions shown in the following Table 1. The prepared monofilament in the segmented pie form was warped with 150 yarns / 7″ beam to prepare the mesh according to the above warp knitted texture of Example 1. The prepared mesh was cured at 150° C. for 5 minutes. The properties of the mesh, such as thickness, weight, tensile strength, and stiffness were determined according to the conventional measuring methods, and the results are shown in the following Table 6.

TABLE 1glycolide (75) / caprolactonePolymerpolypropylene(25) copolymerMelt index (g / 10 min, 230° C.)1013Spinning ConditionsExtruderExt. 1Ext. 2The number of segments of the non-6—degradable polymerPre-pump pressure (kgf / cm2)8080Temperature inZone 1150150Extruder (° C.)Zone 2160165Zone 3170...

example 2

[0061] The monofilament in the segmented pie form was prepared through conjugated spinning of 55 vol % of a glycolide (75) / caprolactone (25) copolymer as a degradable polymer and 45 vol % of a propylene (97) / ethylene (3) copolymer as a non-degradable polymer under the conditions shown in the following Table 2. The prepared monofilament in the segmented pie form was warped with 120 yarns / 7″ beam to prepare the mesh according to the above warp knitted texture of Example 2. The prepared mesh was cured at 155° C. for 3 minutes. The properties of the mesh, such as thickness, weight, tensile strength, and stiffness were determined according to the conventional measuring methods, and the results are shown in the following Table 6.

TABLE 2Propylene (97) / ethylene (3)Glycolide (75) / randomcaprolactone (25)PolymercopolymercopolymerMelt index (g / 10 min, 230° C.)812Spinning ConditionsExtruderExt. 1Ext. 2The number of segments of the non-6—degradable polymerPre-pump pressure (kgf / cm2)8080Temperat...

example 3

[0062] The monofilament in the segmented pie form was prepared through conjugated spinning of 55 vol % of a dioxanone (90) / trimethylenecarbonate (9) / caprolactone (1) tri-block copolymer as a degradable polymer and 45 vol % of polypropylene as a non-degradable polymer under the conditions shown in the following Table 3. The prepared monofilament in the segmented pie form was warped with 120 yarns / 7″ beam to prepare the mesh according to the above warp knitted texture of Example 3. The prepared mesh was cured at 95° C. for 10 minutes. The properties of the mesh, such as thickness, weight, tensile strength, and stiffness were determined according to the conventional measuring methods, and the results are shown in the following Table 6.

TABLE 3Dioxanone (90) / trimethylene-carbonate (9) / caprolactonepoly-(1) tri-blockPolymerpropylenecopolymerMelt index (g / 10 min, 230° C.)1010Spinning ConditionsExtruderExt. 1Ext. 2The number of segments of the non-6—degradable polymerPre-pump pressure (kgf...

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Abstract

The present invention relates to a monofilament with a segmented pie structure formed by conjugated spinning of degradable polymers and non-degradable polymers, a hernia mesh having improved flexibility and biocompatibility, and a preparation method thereof. More specifically, the hernia mesh of the present invention having improved flexibility and biocompatibility is prepared using the monofilament obtained by conjugated spinning of degradable polymers and non-degradable polymers into a segmented pie form, to control it to be gradually degraded in the body, whereby the stiffness of the early stage is removed, and thereby the foreign body sensation is also removed.

Description

BACKGROUND OF THE INVENTION [0001] (a) Field of the Invention [0002] The present invention relates to a monofilament having a segmented pie structure formed by conjugated spinning of degradable polymers and non-degradable polymers, a hernia mesh comprising the monofilament having improved flexibility and biocompatibility, and a method for preparing the same. More specifically, the present invention relates to a monofilament prepared by conjugated spinning of degradable polymers and non-degradable polymers in the form of a segmented pie; a hernia mesh that is prepared with the monofilament and that is controlled to be gradually degraded in the body while losing the stiffness of the early stage, causing no misfeelings, and having improved flexibility and biocompatibility; and a method of preparation thereof. [0003] (b) Description of the Related Art [0004] Tension-free hernioplasty (Lichtenstein I L, Am J Surg 1989; 157; 188-193) is considered to be a useful method for reparation of h...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B17/03B29C48/05B29C48/345B29C48/92
CPCA61F2/0063A61F2250/0031A61L31/04A61L31/148B29C2947/92695B29C47/0014B29C47/30B29C47/92D04B21/12B29C48/345B29C48/92B29C48/30B29C48/0018B29C48/05A61L31/041D01D5/30B29C2948/92695A61L31/146A61L2430/34C08L67/04C08L23/10A61F2/0045A61F2/08D01D5/32D02J13/00D10B2509/08D10B2401/12A61F2002/0068A61F2240/002D01D5/12D02J1/228D02G3/448D02J1/22D01D5/0885D01D5/16D01D5/088D02J1/229D01D10/02B29K2023/12B29K2067/04B29K2995/0037B29L2028/00B29L2031/7546D01D5/08D01D10/00D03D7/00D04B1/22
Inventor YEO, GUW-DONGKIM, JUN-BAE
Owner SAMYANG BIOPHARMLS CORP
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