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Tissue bulking and coating compositions

a technology for coating and tissue, applied in the direction of synthetic polymeric active ingredients, prosthesis, catheters, etc., can solve the problems of lack of competence of the lower part, more severe problems, and gastroesophageal reflux diseas

Inactive Publication Date: 2005-06-16
BIOCURE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0002] The invention relates to compositions for use in tissue bulking and coating. More specifically, the invention relates to compositions including crosslinkable macromo

Problems solved by technology

Frequent reflux episodes (two or more times per week), may result in a more severe problem known as gastroesophageal reflux disease (GERD).
The primary cause of GERD is believed to be the lack of competency of the lower esophageal sphincter.
As a person ages, his ability to voluntarily control the sphincter muscle is lost in the same way that general muscle tone deteriorates with age.
This can also occur when a radical event such as paraplegia “disconnects” the parasympathetic nervous system causing a loss of sphincter control.

Method used

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  • Tissue bulking and coating compositions
  • Tissue bulking and coating compositions
  • Tissue bulking and coating compositions

Examples

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Effect test

example 1

Subcutaneous Injection Using Pig Bladder

[0146] Table 1 describes the formulations employed. The macromers were PVA of the molecular weights noted substituted with the noted amounts of N-acrylamidoacetaldehyde dimethyl acetal. The macromers were made substantially as described in U.S. Pat. No. 5,932,674. The formulations were as follows for 10 grams of 10% macromer solutions. The stock solutions were 41.5 μM Fe lactate; 415 μM peroxide, 1 M acetate buffer. pH 4,1. 415 μM ascorbate.

crosslinks pergel timesamplePVAchainformulation(sec)firmness14-88627.701 (most firm)31 kDa24-88632.94131 kDa33-832.516.23214 kDa43-832.545.38214 kDa53-83218.40314 kDa64-88318.47431 kDa74-88346.75431 kDa83-9821165 (least firm16 kDa

1) R (reductant): 300 μl Fe, 160 μl ascorbic acid, 200 μl acetate buffer O (oxidant): 160 μl peroxide, 200 μl buffer

2) R (reductant): 150 μl Fe, 160 μl ascorbic acid, 200 μl acetate buffer O (oxidant): 160 μl peroxide, 200 μl buffer

3) R (reductant): 600 μl Fe, 160 μl ascorbic ...

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Abstract

Compositions comprising macromers having a backbone comprising units having a 1,2-diol and / or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and hydrolyzed copolymers of vinyl acetate, for example, copolymers with vinyl chloride, N-vinylpyrrolidone, etc. The backbone polymer contains pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as agents to hulk and coat tissues.

Description

RELATED APPLICATION [0001] This application claims priority to U.S. Ser. No. 60 / 188,975, filed on Mar. 13, 2000.BACKGROUND OF THE INVENTION [0002] The invention relates to compositions for use in tissue bulking and coating. More specifically, the invention relates to compositions including crosslinkable macromonomers (also referred to herein as macromers) that form hydrogels useful in tissue bulking and coating. The invention also relates to methods for tissue bulking and coating. [0003] There are many instances in which an appropriate biomaterial is needed for use in repair of tissues and in augmentation of tissues. Applications for an appropriate biomaterial include repair of defects and conditions in a tissue caused by disease, injury, or aging, repair of congenital defects and conditions in a tissue, and augmentation of tissues to provide a desirable functional, reconstructive, or cosmetic change. Biomaterials are also needed for sealing tissues to prevent post operation leakage...

Claims

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Application Information

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IPC IPC(8): A61B17/12A61L24/00A61L24/06A61L27/16A61L27/34A61L27/52A61L29/04A61L29/08A61L31/04A61L31/10C08F8/30C08F261/00C08F261/04C08F271/02C08F277/00C08F290/00C08F290/12C08F290/14C08L51/00C08L51/08
CPCA61B17/12022A61B17/12099C08L51/08C08L51/003C08F290/14C08F290/12C08F290/00C08F277/00C08F271/02C08F261/04C08F261/00C08F8/30A61L2430/36A61L31/10A61L31/048A61L29/085A61L29/041A61L27/52A61L27/34A61L27/16A61L24/06A61L24/0031A61B17/1219A61B17/12122A61B17/12186C08L29/04C08L2666/02C08L29/00
Inventor GOUPIL, DENNIS W.CHAOUK, HASSANHOLLAND, TROY T.ASFAW, BRUKTAWIT T.GOODRICH, STEPEHEN D.LATINI, LUCAS
Owner BIOCURE
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