Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

FHIT proteins and nucleic acids and methods based thereon

a technology applied in the field of fhit proteins and nucleic acids and methods based thereon, can solve the problems of hampered isolation of involved gene(s), substantial death and health costs in society, and the overall survival rate has not improved significantly, so as to reduce the expression level or activity of fhit proteins, the effect of reducing the expression level or activity

Inactive Publication Date: 2004-12-30
THOMAS JEFFERSON UNIV
View PDF5 Cites 34 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cancer remains one of the most severe health problems in America, accounting for substantial fatality and health costs in society.
Deletions may cause loss of tumor suppressor genes, leading to malignancy.
However, the observation that allelic losses often involve most of the 3p has hampered the isolation of the involved gene(s).
Lung cancer is a major cause of mortality worldwide and the overall survival rate has not improved significantly in the last 20 years.
Despite the success achieved by primary prevention, lung cancer is still an overwhelming medical and social problem.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • FHIT proteins and nucleic acids and methods based thereon
  • FHIT proteins and nucleic acids and methods based thereon
  • FHIT proteins and nucleic acids and methods based thereon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0045] The present invention relates to nucleotide sequences of PHIT genes and amino acid sequences of their encoded Fhit proteins, as well as derivatives and analogs thereof, and antibodies thereto.

[0046] As described by way of example infra, the present inventors have isolated and characterized a human FHIT gene, that is involved in esophageal, gastric, colon, kidney, and other cancers. Mutations in FHIT gene sequences leading to loss of FHIT gene function are associated with cancer.

[0047] The present invention further relates to the use of FHIT genes and related nucleic acids and their encoded-proteins or derivatives or analogs thereof, and antibodies thereto, in assays for the detection and in treatment / prevention of disease states associated with chromosomal or molecular abnormalities and / or increased expression of FHIT, such as cancer. The present invention also relates to therapeutic compositions comprising Fhit proteins, derivatives or analogs thereof, antibodies thereto, nu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.

Description

[0001] This is a continuation of U.S. patent application Ser. No. 09 / 717,054, filed Nov. 21, 2000, which is a continuation of U.S. patent application Ser. No. 08 / 605,430, filed Feb. 22, 1996, which issued as U.S. Pat. No. 6,242,212 on Jun. 5, 2001, which is a continuation-in-part of U.S. patent application Ser. No. 08 / 598,873, filed Feb. 9, 1996, which issued as U.S. Pat. No. 5,928,884 on Jul. 27, 1999, the entire disclosure of which is incorporated herein by reference.1. INTRODUCTION[0003] The present invention relates to nucleotide sequences of the tumor suppressor FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof and antibodies thereto. The present invention relates to the use of nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof and antibodies thereto, as diagnostic and therapeutic reagents for the detection and treatment of cancer. The present i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/00A61K31/70C12N15/02A61K31/7088A61K38/00A61K48/00A61P1/00A61P11/00A61P13/00A61P13/12A61P15/00A61P19/00A61P35/00C07K14/47C07K16/18C07K19/00C12N1/21C12N5/10C12N15/00C12N15/01C12N15/09C12N15/12C12P21/02C12P21/08C12Q1/68
CPCA61K38/00C07K14/4703C07K16/18C07K2319/00A61P1/00A61P11/00A61P13/00A61P13/12A61P15/00A61P19/00A61P35/00
Inventor CROCE, CARLO M.HUEBNER, FRANCES KAY
Owner THOMAS JEFFERSON UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com