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Natural biodegradable polysaccharide coatings for medical articles

A biological, coating technology, applied in the direction of coating, etc.

Inactive Publication Date: 2007-04-18
SURMODICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

In this patented process for making materials like medicine from naturally occurring compounds it has been found possible to create durability against decomposition caused by water ingress during storage. Natural bioresorbents have also shown promise because they were able to protect certain active components within them when placed inside tissues over time. Additionally, these compositions made through this technology could help prevent diseases if applied externally.

Problems solved by technology

Technologies aimed towards improving the properties and usages of various chemical compounds found within medicine packaging systems involve modifying them chemistry during manufacturing processes. Chemotherapy treatments involving cancer treatment often result in residual quantities of certain medicines being left behind inside patient's bodies after they leave the patients. To address these issues, researchers developed new methods for producing sterilizable/bioreachably coats made of different types of polymers which could overcome challenges faced when trying to create a reliable solution without causing harmful health hazards.

Method used

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  • Natural biodegradable polysaccharide coatings for medical articles
  • Natural biodegradable polysaccharide coatings for medical articles
  • Natural biodegradable polysaccharide coatings for medical articles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0235] Synthesis of Acrylated Amylose

[0236] Amylose with polymerizable vinyl groups was prepared by mixing 0.75 g of amylose (A0512; Aldrich) and 100 mL of dimethyl sulfoxide (JT Baker) in a 250 mL amber bottle, under stirring. One hour later, 2 mL of triethylamine (TEA; Aldrich) was added, and the resulting mixture was stirred at room temperature for 5 minutes. Subsequently, 2 mL of glycidyl acrylate (Polysciences) was added, and amylose and glycidyl acrylate were allowed to react overnight with stirring at room temperature. The mixture containing the amylose-glycidyl acrylate reaction product was dialyzed with DI water using continuous flow dialysis for 3 days. The obtained acrylated amylose (0.50 g; yield 71.4%) was lyophilized and stored at room temperature and protected from light.

Embodiment 2

[0238] Synthesis of MTA-PAAm

[0239] The polymerization initiator is prepared by copolymerizing methacrylamide with photosensitive group and acrylamide.

[0240] Firstly, methacrylamide-oxothixanthene monomer (N-[3-(7-methyl-9-oxothioxanthene-3-formylamino) propyl] methacrylamide (MTA-APMA) is prepared ). In a 250mL round bottom flask equipped with a drying tube, 4.53g (25.4mmol) of N-(3-aminopropyl)methacrylamide hydrochloride (APMA) prepared according to the method described in Example 2 of US Patent No. 5,858,653 ), suspended in 100mL anhydrous chloroform. 7-Methyl-9-oxothixanthene-3-carboxylic acid (MTA) was prepared according to the method described in Example D of US Patent No. 4,506,083. MTA-chloride (MTA-Cl) was prepared according to the method described in Example 1 of US Patent No. 6,007,833. After cooling the slurry in an ice bath, solid MTA-Cl (7.69 g; 26.6 mmol) was added to the APMA-chloroform suspension under stirring. Then, a solution containing 7.42 mL...

Embodiment 3

[0243] Formation of amylose coating

[0244] 100 mg of the acrylated amylose prepared in Example 1 was placed in an 8 mL amber bottle. Add 3 mg MTA-PAAm (lyophilized), 2 μL of 2-NVP (N-vinyl-2-pyrrolidone; accelerator (Bimax)) and 1 mL of 1X phosphate buffered saline ( 1X PBS). The reagents were then mixed on a shaker at 37°C for 1 hour. Place 50μL of the mixture on a glass slide (2991FI; Esco), and use a 400-500nm filter (50mW / cm 2 ) The EFOS 100 SS lighting system is illuminated for 50 seconds. After exposure to light, the polymer was found to form a semi-hard gel with elastomer properties.

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Abstract

Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.

Description

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Claims

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Application Information

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Owner SURMODICS INC
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