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Technology for preparing compound human inter feron spray agent capable of preventing polytypic influenza

A technology of spray and interferon, which is applied in the field of production of spray-type compound interferon, and can solve the problems of widely varying degrees of sensitivity

Inactive Publication Date: 2007-03-28
北京远策药业有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, in the same cell or body, interferon has a certain effect on a variety of DNA and RNA viruses, but its sensitivity varies widely.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Interferon spray prescription 1:

[0054] Human recombinant interferon α2b: 3 million units / ml

[0055] Chitosan 0.5% (purchased from American Sigma company): molecular weight is 150kD, deacetylation is above 85%,

[0056] Human recombinant interleukin 2: 200,000 units / ml

[0057] Human serum albumin: 0.5%

[0058] Phosphate buffer solution: 0.05M, its pH value is 6.5-7.0.

[0059] Benzyl alcohol: 0.5%

Embodiment 2

[0061] Interferon spray prescription 2:

[0062] Human recombinant interferon α1b: 300 micrograms / ml

[0063] Chitosan 0.5% (purchased from American Sigma company): molecular weight is 150kD, deacetylation is above 85%,

[0064] Human recombinant interleukin 2: 200,000 units / ml

[0065] Human serum albumin: 0.5%

[0066] Phosphate buffer solution: 0.05M, its pH value is 6.5-7.0.

[0067] Benzyl alcohol: 0.5%

Embodiment 3

[0069] Interferon spray prescription 2:

[0070] Human recombinant interferon β1b: 1 million units / ml

[0071] Chitin 0.5% (purchased from American Sigma company): molecular weight is 150kD, deacetylation is over 85%, human recombinant interleukin 2: 200,000 units / ml

[0072] Human serum albumin: 0.5%

[0073] Phosphate buffer solution: 0.05M, its pH value is 6.5-7.0.

[0074] Benzyl alcohol: 0.5%

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Abstract

The present invention provides a novel human compound interferon spray for preventing and curing various types of influenza virus infection and its production preparation method. The described human compound interferon spray composition includes various types of human interferon alpha or beta or gamma or omega or delta or epsi or kappa or lambda etc. human interleukin-2, natural polysaccharide, human alhumin and preservative substance. The described influenza virus includes human influenza virus and avian influenza virus type A and type B. The invented human compound interferon spray can obtain obvious effect for preventing and curing various types of influenza virus infection.

Description

Technical field: [0001] The invention relates to a production technology of spray-type compound interferon, which belongs to the field of pharmaceutical preparations. Background technique: [0002] Influenza (flu) has the characteristics of sudden occurrence and rapid spread. Smaller cases may be localized, and large cases may spread all over the world. At the same time, it is easy to cause complications. In severe cases, it can lead to death, which is very harmful. Immunization is an effective way to prevent influenza. Influenza prevention has always been a global public health problem. The application of influenza vaccines for immunization prevention has received more and more attention. [0003] In the last century, there were 3 influenza pandemics in the world: the Spanish influenza in 1918-1919; the Asian influenza in 1957; and the Hong Kong influenza in 1968. The Spanish flu epidemic of 1918-1919 killed about 50 million people in just 11 months. At present, the World Health...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61K9/12A61P31/16
Inventor 侯云德张丽兰段招军
Owner 北京远策药业有限责任公司
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